A Model of the Cortico-Basal Ganglia Network and Local Field Potential during Deep Brain Stimulation

Dunn, Eleanor ;   Lowery, Madeleine

Tags Deep brain stimulationBrain physiology and modeling – Neuron modeling and simulationNeuromuscular systems – Computational modeling and simulation

Oscillatory neural activity in the beta frequency band (12-30 Hz) is elevated in Parkinson's disease and is correlated with the associated...

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Analysis of Computational Models of Deep Brain Stimulation using Spherical Statistics

Xiao, YiZi ;   Johnson, Matthew

Tags Deep brain stimulationBrain physiology and modeling – Neuron modeling and simulation

Computational models of deep brain stimulation (DBS) have played a key role in investigating the mechanisms of action of DBS therapies. By...

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Closed-Loop DBS with Movement Intention

Herron, Jeffrey ;   Denison, Timothy ;   Chizeck, Howard

Tags Deep brain stimulationNeural interfaces – Implantable systemsNeurological disorders

In this paper we present a prototype proof-of-concept for a closed-loop deep brain stimulation system for patients with essential tremor....

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Design of a Novel Closed-Loop Deep Brain Stimulation System for Parkinson's Disease and Obsessive-Compulsive Disorder

Karamintziou, Sofia ;   Piallat, Brigitte ;   Chabardes, Stephan ;   Polosan, Mircea ;   David, Olivier ;   Tsirogiannis, George ;   Deligiannis, Nikolaos ;   Stathis, Pantelis ;   Tagaris, George ;   Boviatsis, Efstathios ;   Sakas, Damianos ;   Polychronaki, Georgia – Stavroula ;   Nikita, Konstantina

Tags Deep brain stimulationNeural interfaces – Computational modeling and simulationNeurological disorders

We present a novel closed-loop subthalamic nucleus (STN) deep brain stimulation (DBS) scheme for Parkinson's disease (PD) and...

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Guiding Deep Brain Stimulation Contact Selection using Local Field Potentials Sensed by a Chronically Implanted Device in Parkinson's Disease Patients

Connolly, Allison ;   Kaemmerer, Bill ;   Dani, Siddharth ;   Stanslaski, Scott ;   Panken, Eric ;   Johnson, Matthew ;   Denison, Timothy

Tags Deep brain stimulationNeural interfaces – Implantable systemsNeural signal processing – Nonlinear analysis

We have found that a set of support vector machines operating upon local field potentials sensed from an implanted DBS lead can identify the...

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Simulating the Therapeutic Effects of Deep Brain Stimulation in Rodents using a Cortico-Basal Ganglia Network and Volume Conductor Model

Schmidt, Christian ;   Dunn, Eleanor ;   Lowery, Madeleine ;   van Rienen, Ursula

Tags Deep brain stimulation

Models of the cortico-basal ganglia network and volume conductor models of the brain can help to gain insight into the mechanisms of action...

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