A Magnetic Microparticle Capture and Liposome-Based Impedance Sensing Device for Detection of Viruses in Blood

Damhorst, Gregory ;   Sobieraj, Magdalena ;   Chaves, Rodrigo ;   Kooiman, Jonathan ;   Smith, Cartney ;   Kong, Hyunjoon ;   Bashir, Rashid

Tags Global healthMicrofluidicsDiagnostics

Low-cost, rapid detection of viruses in blood at the point-of-care remains a challenge and an unmet global need in the management of a...

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A New Competitive Fluorescence Immune-Assay for Detection of Listeria Monocytogenes

Lacroix, Monique ;   D'Auria, Sabato

Tags Diagnostics

A new competitive immune assay has been designed using a specific monoclonal antibody (anti-p60 IgG) labeled with a fluorophore. A specific and...

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An Image Reconstruction Method Using Singular Value Decomposition for Magnetic Particle Imaging

Shimizu, Shota ;   Tsuchiya, Hiroki ;   takagi, tomoyuki ;   Hatsuda, Tomoki ;   Noguchi, Tomoaki ;   Ishihara, Yasutoshi

Tags DiagnosticsNanotechnologyMicrofluidics

Magnetic particle imaging is a medical imaging technology suitable for noninvasive diagnostics. However, the image resolution was degraded due...

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An Optically Transparent Micro-Ring Ultrasonic Detection Enables Isometric Multimodal Photoacoustic Microscopy

Dong, Biqin ;   Li, Hao ;   Zhang, Hao ;   Sun, Cheng

Tags NanotechnologyMicrofabricationDiagnostics

A cover-slip type transparent optical ultrasonic detector based on a polymeric micro-ring resonator was developed for achieving optical...

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Assessments of T-Nanowire Transistor Assay for Clinical Diabetic Nephropathy

Mao, Yufei ;   Shin, Kyeong-Sik ;   Nicholas, Susanne ;   Chui, Chi On

Tags DiagnosticsLab-on-ChipBionanotechnology

For the first time, we assessed the amplifying T-nanowire transistor assay in quantitating a key diabetic kidney disease (DKD) urinary...

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Charge Coupled pH Monitoring in Thin-Film Dual-Gated ISFETs

Duarte-Guevara, Carlos ;   Lai, Fei-Lung ;   Reddy, Bobby ;   Salm, Eric ;   Vilasur Swaminathan, Vikhram ;   Liu, Yi-Shao ;   Bashir, Rashid

Tags DiagnosticsLab-on-ChipPoint-of-care

Reference electrodes, that are required for the operation of ion-sensitive field-effect transistors, are unreliable and too large for droplet...

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Compartmentalized Single Cell Analysis – Antibiotic Susceptibility and Protein Screening

Andersson Svahn, Helene

Tags MicrofluidicsLab-on-ChipDiagnostics

Droplet microfluidics is a technological platform that utilizes monodisperse aqueous droplets in a continuous biocompatible oil phase as...

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Democratization of Next-Generation Imaging, Diagnostics and Measurement Tools through Computational Photonics

Ozcan, Aydogan

Tags Global healthBionanotechnologyDiagnostics

My research focuses on the use of computation/algorithms to create new optical microscopy, sensing, and diagnostic techniques, significantly...

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Design and Simulation of Device for Breach Microfluidics Membrane for the Detection of Hiv (aids)

Lagos, Jose ;   Leguizamon, Ana ;   Quiroga, Daniel

Tags DiagnosticsLab-on-ChipMicrofluidics

This article present a model of diagnostic device that using chemical reagents and microfluidics as particle separation is developed to...

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Digital Drug Dosing: Dosing in Drug Assays by Light-Defined Volumes of Hydrogels with Embedded Drug-Loaded Nanoparticles

Faralli, Adele ;   Melander, Fredrik ;   Larsen, Esben Kjær Unmack ;   Andresen, Thomas Lars ;   Larsen, Niels Bent

Tags DiagnosticsBionanotechnologyPoint-of-care

Polyethylene glycol (PEG)-based hydrogels are widely used for biomedical applications, including matrices for controlled drug release. We...

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Droplet Libraries for Digital PCR with Improved Dynamic Range

Kaminski, Tomasz S. ;   Postek, Witold ;   Debski, Pawel R. ;   Garstecki, Piotr

Tags MicrofluidicsLab-on-ChipDiagnostics

This paper reports a microfluidic system that i) generate a sequence of 20 microliter droplets of a 2-fold dilution of DNA concentration ii)...

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Electrical Phenotypes and Polymyxin Resistance of Pseudomonas Aeruginosa Clinical Isolates

Wang, Qianru ;   Moskowitz, Samuel ;   Buie, Cullen Richard

Tags MicrofluidicsDiagnostics

Recently we've demonstrated insulator based dielectrophoresis with strain-level discrimination of the opportunistic human pathogen Pseudomonas...

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Electrochemical Sensors for Point-of-Care Metal Determination

Kang, Wenjing ;   Pei, Xing ;   Rusinek, Cory ;   Bange, Adam ;   Haynes, Erin ;   Heineman, William ;   Papautsky, Ian

Tags Point-of-careDiagnosticsGlobal health

In this work, we report on development of a sensor for electrochemical determination of heavy metals. Our sensor features a new, low-cost...

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HemeChip for Early Diagnosis of Sickle Cell Disease in Newborns

Alapan, Yunus ;   Ung, Ryan ;   Romelfanger, Megan ;   Piccone, Connie ;   Little, Jane ;   Gurkan, Umut A.

Tags DiagnosticsPoint-of-careLab-on-Chip

More than 800 children are born with Sickle Cell Disease (SCD) every day in Africa, and more than half of them die in childhood due to lack of...

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Integrated Respiratory Signal Monitoring and Apnea Detection System Using Pyroelectric Sensor

Mahbub, Ifana ;   Pullano, Salvatore A. ;   Ruberto, Francesco ;   Hasan, Md Sakib ;   Farhan, Quaiyum ;   Christopher P., Stephens ;   Gary, To ;   Syed Kamrul, Islam ;   Fiorillo, Antonino S. ;   Mark S., Gaylord ;   Vichien, Lorch

Tags Global healthDiagnosticsPoint-of-care

The paper presents a fully integrated system for apnea detection of neonatal infants. Apnea has been one of the leading causes of death in...

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Low-Dosages of Zeolite 13X Produce a Bimodal Effect on Breast Cancer Cells: Geno-Oxidative Damage and Reduction of Lipid Peroxidation

Malara, Natalia, Maria ;   Tiriolo, Raffaele ;   Trunzo, Valentina ;   Pullano, Salvatore A. ;   Elisabetta, Dattola ;   Paola, Failla ;   di Fabrizio, Enzo ;   Mollace, Vincenzo ;   Fiorillo, Antonino S.

Tags DiagnosticsNanotechnology

Zeolite is a nanoporous material possessing excellent properties for application in medical and biological engineering. The effects of low...

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Microfluidic Single Sperm Entrapment and Analysis

de Wagenaar, Bjorn ;   Berendsen, Jorien ;   Huisintveld, Nik ;   Olthuis, Wouter ;   van den Berg, Albert ;   Segerink, Loes Irene

Tags MicrofluidicsBionanotechnologyDiagnostics

This abstract describes the hydrodynamic trapping of single spermatozoa in a microfluidic platform, allowing the investigation of sperm...

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Microfluidic, Multifunctional, Multilayer, Monodisperse Microbubbles

Lee, Abraham ;   Hettiarachchi, Kanaka ;   Bardin, David ;   Shih, Roger

Tags MicrofluidicsNanomedicineDiagnostics

In this talk I will review my lab's development of microfluidic technology for multilayer vesicles (MVs), focusing on gaseous-cored microbubbles....

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Multiplexed SERS for Rare Cell Detection in Flow

Hoonejani, Mehran ;   Pallaoro, Alessia ;   Braun, Gary ;   Moskovits, Martin ;   Meinhart, Carl

Tags NanotechnologyMicrofluidicsDiagnostics

The reliable and fast identification of different types of cells is of utmost importance in several biomedical applications. The detection of...

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Non-Invasive Genetic Characterization of Bladder Cancer Using Urine Samples towards Improved Clinical Management of Patients

Raillon, Camille ;   Derré, Laurent ;   Nardelli Haefliger, Denise ;   Jichlinski, Patrice ;   Schoumans, Jacqueline

Tags DiagnosticsMicrofabricationGlobal health

The goal of this study is both to detect and follow bladder cancer patients using a non-invasive genetic test. Our hypothesis is that urine...

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Optical Cell Separation from 3D Culture Environment in Photodegradable Hydrogels for Pure Culture Techniques

Tamura, Masato ;   Yanagawa, Fumiki ;   Sugiura, Shinji ;   Takagi, Toshiyuki ;   Sumaru, Kimio ;   Matsui, Hirofumi ;   Kanamori, Toshiyuki

Tags Tissue engineeringDiagnostics

We present a new methodology for optical cell picking in 3D culture environment. In this study, we encapsulated cells in photodegradable...

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Physical Phenotyping of Single-Cells for Biomedicine

Di Carlo, Dino

Tags MicrofluidicsStem cellsDiagnostics

Physical properties of cells can provide integrative and quantitative information about various disease states. I will discuss a range of...

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Real Time Impedance Sensing of Intermediate Stages of Mitosis of a Single Cell

Kaji, Hirokazu ;   Ghenim, Lamya ;   Nagamine, Kuniaki ;   Porte, Stephanie ;   Haguet, Vincent ;   Gidrol, Xavier ;   Nishizawa, Matsuhiko

Tags Lab-on-ChipDiagnostics

We have constructed a sensitive tool to monitor electrically changes of individual cells by combining electrochemical-based surface modification...

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Real-Time Detection and Closed Loop Feedback of Biomolecules in Live Animals

Soh, H. Tom

Tags DiagnosticsPoint-of-careMicrofluidics

A biosensor capable of continuously measuring specific molecules in the bloodstream in vivo would give clinicians a valuable window into...

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Roll-to-Roll Shrink-Induced Superhydrophobic Surfaces for Enhanced Point-of-Care Detection in Urine

McLane, Jolie ;   Wu, Chun ;   Liedert, Ralph ;   Khine, Michelle

Tags Point-of-careDiagnosticsBionanotechnology

Superhydrophobic (SH) features have been created in hard plastic by depositing metal on shrink film. These features are scaled up for...

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Sol-Gel Derived Silica Structures for Enhanced Fluorescence Sensing

Lin, Sophia ;   Khine, Michelle

Tags DiagnosticsMicrofabricationNanotechnology

Efforts to improve the detection sensitivity and signal-to-noise ratios (SNRs) of low-abundance target molecules have resulted in engineered...

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Stereolithographic Manufacture of Microneedle Patch Arrays for Blood Collection

Faraji Rad, Zahra ;   Davies, Graham ;   Anthony, Carl ;   Prewett, Philip D ;   Nordon, Robert E

Tags MicrofabricationDiagnosticsLab-on-Chip

3D laser lithography is used to manufacture microneedle master molds with optimal geometric designs for collection of subcutaneous capillary...

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Super-Resolved Micro-Vascular Imaging Using Microbubbles and Machine Learning

Christensen-Jeffries, Kirsten ;   Schirmer, Markus D ;   Browning, Richard ;   Tang, Meng-Xing ;   Dunsby, Christopher ;   Aljabar, Paul ;   Eckersley, Robert John

Tags MicrofluidicsDiagnostics

Recent developments in sub-diffraction ultrasound (US) imaging using clinical US systems has shown the potential to resolve structures on the...

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Targeted Magnetic Resonance Imaging through Nanodiamonds

Moore, Laura ;   Towsend, Taryn R. ;   Meade, Thomas J. ;   Ho, Dean

Tags NanomedicineNanotechnologyDiagnostics

Steroid hormone receptors play a key role in the prognosis and treatment of a variety of cancers including breast, ovarian and prostate....

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Targeting Survivin: A SPION-Based Approach to Cancer Diagnostics and Therapy

Despeaux, Emily ;   Talbott, Siera ;   Gannett, Peter ;   Pisane, Kelly ;   Seehra, Mohindar ;   Carroll, R. Lloyd

Tags NanomedicineDiagnosticsBionanotechnology

Magnetic nanoparticles, including superparamagnetic iron oxide nanoparticles (SPION), have the potential to significantly improve the diagnosis...

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The New Evaluation Method of Intestinal Absorption Used by Spectroscopic Imaging in Animal Production Science

Takagi, Ryo ;   Matsumoto, Yoshiki

Tags Diagnostics

Morphological aspects of gastrointestinal tract were well analyzed the response of digestive juice and applied in the feed supplement...

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Three-Dimensional Textured Graphene Bioelectronics

Wang, Michael Cai ;   Choi, Jonghyun ;   Yong, Keong ;   Ashraf, Ali ;   Nam, SungWoo

Tags NanotechnologyBionanotechnologyDiagnostics

Superb electromechanical properties of graphene, where large elastic deformation is achievable without significant perturbation of electrical...

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Towards a Diffusion-Based Microfluidic Device for Isolation of Cell-Derived Microparticles

Cherré, Solène ;   Olsen, Mark ;   Noemi, Rozlosnik

Tags MicrofluidicsDiagnosticsNanomedicine

Cell-derived microparticles (MPs) have been proposed as novel diagnostics biomarkers for a wide range of diseases. However instruments and...

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Wireless Power Transfer System for Endoscopic Capsule Robot

Park, Wanjoo ;   Kim, Laehyun

Tags Diagnostics

Robotic capsule endoscopy is a revolutionary procedure for examining the entire gastrointestinal tract by active locomotion of the capsule...

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