3D Microelectrodes on Chip for Impedance-Based Cell Detection and Differentiation

Rollo, Enrica ;   Wilhelm, Jannick ;   Guiducci, Carlotta

Tags MicrofabricationLab-on-ChipMicrofluidics

In this work we show single-particle differentiation in flow based on size and cell state by means of on-chip 50 µm high 3D silicon micropillar...

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3D-Bioengineering of the Conventional Outflow Tract as Model for High-Throughput Drug Screening

Cula, Dautriche ;   Susan, Sharfstein ;   Xie, Yubing ;   Bergkvist, Magnus ;   Kerr, Matthew ;   Szymanski, Dennis ;   Danias, John ;   Stamer, W. D.

Tags Tissue engineeringRegenerative medicineMicrofabrication

Glaucoma remains the leading cause of irreversible blindness worldwide. Glaucoma is characterized by chronic degeneration of axons of the...

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A Fabrication Platform for Stretchable Electronic Medical Devices

Savov, Angel ;   Khoshfetrat Pakazad, Saeed ;   Joshi, Shivani ;   Henneken, Vincent ;   Dekker, Ronald

Tags MicrofabricationBioMEMSLab-on-Chip

A CMOS compatible post-processing technology for the fabrication of high-density stretchable electronic circuits is demonstrated. The...

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All-Polymer, High-Aspect-Ratio, Soft Lithography

Bubendorfer, Andrea ;   Best, Andrew ;   Arnold, William Michael

Tags MicrofabricationLab-on-ChipBioMEMS

Microfluidic ?chips? are commonly produced by molding or embossing from master structures: the masters need to be able to withstand many...

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An Optically Transparent Micro-Ring Ultrasonic Detection Enables Isometric Multimodal Photoacoustic Microscopy

Dong, Biqin ;   Li, Hao ;   Zhang, Hao ;   Sun, Cheng

Tags NanotechnologyMicrofabricationDiagnostics

A cover-slip type transparent optical ultrasonic detector based on a polymeric micro-ring resonator was developed for achieving optical...

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Application of Silicon Microwire Arrays in Characterization of Skeletal Muscle Tissue

Banan Sadeghian, Ramin ;   Ostrovidov, Serge ;   Oi, Hideo ;   Kawano, Takeshi ;   Khademhosseini, Ali

Tags Tissue engineeringMicrofabricationLab-on-Chip

We report on the establishment of skeletal muscle cell cultures on silicon (Si) microwire arrays grown by a vapor-liquid-solid (VLS) technique....

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Brain Stem Cell Interaction with Nanostructured Poly-Si/Pt Surfaces

Bérces, Zsófia ;   Horváth, Ágoston Csaba ;   Jády, Attila Gyula ;   Pongrácz, Anita ;   Madarász, Emília ;   Fekete, Zoltán

Tags NanotechnologyBionanotechnologyMicrofabrication

In this work, we investigate the biocompatibility of platinized poly-silicon surfaces with different nanoscale textures using NE-4C cell culture....

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Cytodetachment Technique Using Ultrasonic Vibration

Kurashina, Yuta ;   Takemura, Kenjiro ;   Miyata, Shogo ;   Komotori, Jun ;   Koyama, Tadayoshi

Tags BionanotechnologyMicrofabricationTissue engineering

Ultrasonic vibration is often used in tissue engineering, for example, to provide effective mechanical stimuli for cell growth. This study aims...

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Detection of PCR Amplification by Top-Down Silicon Nanowires Field Effect Transistors

Accastelli, Enrico ;   Spiga, Fabio Mario ;   Ernst, Thomas ;   Guiducci, Carlotta

Tags Point-of-careMicrofabricationLab-on-Chip

We propose the implementation of PCR system measuring DNA amplification by using top-down, CMOS compatible SiNWs. The DNA amplification cycles...

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Development of Brain-on-a-Chip System based on Microfluidic Perfusion of Organotypic Hippocampal Cultures

Liu, Jing ;   Berdichevsky, Yevgeny

Tags Lab-on-ChipMicrofluidicsMicrofabrication

We developed a microfluidic perfusion system to maintain viable organotypic hippocampal cultures. This system is compatible with multiple...

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Digital and Multiplexed Protein Quantification by Microfluidic Very Large Scale Integration

Araci, Ismail Emre ;   Robles, Michael C. ;   Quake, Stephen

Tags Lab-on-ChipMicrofluidicsMicrofabrication

We have designed and fabricated a reusable digital protein detection platform and demonstrated its usage for b-galactosidase expression...

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Elasticity Tunable Hybrid Hydrogels Using Light Irradiation

Yanagawa, Fumiki ;   Mizutani, Takeomi ;   Sugiura, Shinji ;   Takagi, Toshiyuki ;   Sumaru, Kimio ;   Kanamori, Toshiyuki

Tags Tissue engineeringMicrofabrication

This paper reports a novel technique to synthesize elasticity tunable hybrid hydrogels with an activated-ester-type photocleavable...

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Experimental Analysis of Temperature Dependent Ultrasound Microbeam Trapping Mechanism of Biocompatible Microdroplet by Dual Element Focused Ultrasonic Transducer

Hwang, Jae Youn ;   Lee, Jungwoo

Tags BionanotechnologyBioMEMSMicrofabrication

An experimental study is carried out by using a 20/40 MHz LiNbO3 dual element focused transducer to examine the quantitative relation...

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Fabrication of Biomimetic 3D Liver Tissue by Photodegradable Hydrogels and Perfusion Culture in a Microfluidic Device

Yanagawa, Fumiki ;   Sugiura, Shinji ;   Takagi, Toshiyuki ;   Sumaru, Kimio ;   Kanamori, Toshiyuki

Tags MicrofluidicsTissue engineeringMicrofabrication

This paper reports a novel technique to fabricate perfusable 3D liver tissue in a microfluidic device using photodegradable hydrogels prepared...

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Flexible Strain Sensors for Measuring Contractility Force of Human Stem Cell-Derived Cardiomyocytes

Mendoza, Nicole ;   Carlos, Ruiz ;   Tang, William C. ;   Khine, Michelle

Tags Stem cellsLab-on-ChipMicrofabrication

Contractility assessment of stem cell-derived cardiomyocytes is required to characterize their maturity and functional behavior in vitro. We...

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Flexible, Printable, and Biocompatible CNT-Based Conductive Ink for Fabrication of Supercapacitors and Biosensors

Shin, Su-Ryon ;   Farzad, Razieh ;   Monaharan, Vijian ;   Tamayol, Ali ;   Zhang, Yu Shrike ;   Duck jin, Kim ;   Annabi, Nasim ;   Comotto, Mattia ;   Akbari, Mohsen ;   Dokmeci, Mehmet R. ;   Khademhosseini, Ali

Tags NanotechnologyBionanotechnologyMicrofabrication

ABSTRACT--Multifunctional carbon nanotubes (CNTs) composite materials are currently of considerable interest in fabrication of flexible...

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In Vitro Evaluation of Catheter Design for an Implantable Solid Drug Delivery Pump

Shahhaidar, Ehsaneh ;   Horlen, Kyle ;   Morales, Mercedes ;   Spehr, Paul ;   Morgan, Philip ;   Imran, Mir ;   Fischer, Elmar ;   Schaefbauer, Alyssa ;   Beraki, Simret

Tags Point-of-careMicrofluidicsMicrofabrication

A fully implantable automatic solid drug delivery device offers unique treatment options to patients suffering from chronic conditions. One...

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Indirect Fabrication of Three-Dimensional Hydrogel Constructs for Tissue Engineering Applications

Pimentel Carletto, Rodrigo ;   Muhammad, Haseena Bashir ;   Wolff, Anders ;   Dufva, Martin ;   Emnéus, Jenny ;   Okkels, Fridolin

Tags Tissue engineeringMicrofabrication

We present a three-dimensional (3D) tissue-engineering construct, realized using an indirect fabrication technique. By using fused deposition...

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Magnetic Guidance of Temozolomide-Containing Particles through Brain Tissue

Mair, Lamar ;   Weinberg, Irving ;   Nacev, Alek ;   Stepanov, Pavel ;   Urdaneta, Mario ;   Hilaman, Ryan ;   Himmelfarb, Stephanie ;   Diaz-Caballero, Elena ;   Rigla, Juan Pablo ;   Kulkarni, Sandip ;   Shapiro, Benjamin

Tags NanomedicineNanotechnologyMicrofabrication

Temozolomide (TMZ) is an FDA approved drug for treatment of brain tumors. Encapsulation of this drug in a magnetic nanoparticle carrier has...

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Mechanical Force Induced Transition of Cell Protrusions from Blebs to Lamellipodia

Yeh, Chuan-Feng ;   Juang, Duane ;   Hsu, Chia-Hsien

Tags MicrofabricationLab-on-ChipBioMEMS

Cancer cells exhibit highly diverse types of membrane protrusions during metastasis and invasion1. Both chemical2 and physical signals in the...

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Micropatterning of Cells into Microwells for Metabolic Profiling

Wang, Kuo-chen ;   Meldrum, Deirdre ;   Wang, Hong ;   Chao, Shih-Hui ;   Tian, Yanqing ;   Song, Ganquan

Tags MicrofabricationMicrofluidicsLab-on-Chip

We present a photolithography-based method for micropatterning cells into microwells for metabolic profiling.

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Needle Microelectrodes for Electromyography Recording from Zebrafish Larvae

Cho, Sung-Joon ;   Nam, Tae-Seung ;   Choi, Seok-Yong ;   Kim, Myoung-Kyu ;   Kim, Sohee

Tags MicrofabricationBionanotechnologyNanotechnology

Electromyography (EMG) is the most effective tool in diagnosing muscular diseases, and it is an essential tool in developing treatment agents...

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Non-Invasive Genetic Characterization of Bladder Cancer Using Urine Samples towards Improved Clinical Management of Patients

Raillon, Camille ;   Derré, Laurent ;   Nardelli Haefliger, Denise ;   Jichlinski, Patrice ;   Schoumans, Jacqueline

Tags DiagnosticsMicrofabricationGlobal health

The goal of this study is both to detect and follow bladder cancer patients using a non-invasive genetic test. Our hypothesis is that urine...

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Pneumatic and Hydraulic MRI-Compatible Micromanipulator System and Its MRI-Compatibility

Wong, Kahngee ;   Koseki, Yoshihiko ;   Yamauchi, Yasushi

Tags Microfabrication

 This paper presents a micromanipulator system designed for use in magnetic resonance imaging (MRI) environments in order to enable...

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Projection Micro-Stereolithography Apparatus for High-Resolution 3D Patterning of Cells: Applications in Vascular Tissue Engineering

Raman, Ritu ;   Bhaduri, Basanta ;   Shkumatov, Artem ;   Kong, Hyunjoon ;   Popescu, Gabriel ;   Bashir, Rashid

Tags MicrofabricationBionanotechnologyTissue engineering

We have developed a projection micro-stereolithography apparatus (microSLA) capable of patterning cells encapsulated in biocompatible...

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Sol-Gel Derived Silica Structures for Enhanced Fluorescence Sensing

Lin, Sophia ;   Khine, Michelle

Tags DiagnosticsMicrofabricationNanotechnology

Efforts to improve the detection sensitivity and signal-to-noise ratios (SNRs) of low-abundance target molecules have resulted in engineered...

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Stereolithographic Manufacture of Microneedle Patch Arrays for Blood Collection

Faraji Rad, Zahra ;   Davies, Graham ;   Anthony, Carl ;   Prewett, Philip D ;   Nordon, Robert E

Tags MicrofabricationDiagnosticsLab-on-Chip

3D laser lithography is used to manufacture microneedle master molds with optimal geometric designs for collection of subcutaneous capillary...

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The Axonal Spatial-Temporal Reactive Assembly (astra)

Morgera, Salvatore Domenic

Tags NanotechnologyMicrofabricationNanomedicine

An emerging intersection of the neuroengineering of nerve fiber (axon) tracts/bundles and communications networks is described. At the...

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The Development of an Optopiezoelectric Micropump for Microfluidic Applications

Wang, Hsin-Hu ;   Lee, Chih-Kung ;   Hsu, Yu-Hsiang

Tags MicrofluidicsMicrofabricationLab-on-Chip

In this paper, we present a polymer-based piezoelectric micropump that can be selectively activated and controlled by a masked light source....

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