An Engineered Microfluidic Device for Modeling Cardiac Tissues

Acun, Aylin ;   Zorlutuna, Pinar

Tags MicrofluidicsStem cellsTissue engineering

Studying the heart tissue is critical for understanding and developing treatments for cardiovascular diseases. In this work, we present a...

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An iPS-derived, Vascularized Cardiac Tissue as an in vitro Drug Screening Platform

Kurokawa, Yosuke ;   Tran, David ;   Moya, Monica ;   Sobrino, Agua, Agua ;   Alonzo, Luis ;   Tu, Christina ;   Lock, Leslie ;   Hughes, Christopher ;   Conklin, Bruce ;   George, Steven

Tags Tissue engineeringStem cellsMicrofluidics

Drug attrition due to cardiac toxicity is prevalent, and a better preclinical screening tool is required in order to solve this issue. Here we...

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Electrical Pacing of 3D Ips-Derived Cardiomyocytes and Endothelial Cells in a Microfluidic Device

Lam, Sandra ;   Simon, Melinda ;   Tran, David ;   Alonzo, Luis ;   Flohn, Nicholas ;   Lee, Abraham ;   George, Steven

Tags MicrofluidicsStem cellsTissue engineering

Tissue engineering models of human tissue have frequently utilized microfabricated systems to accurately and consistently provide simultaneous...

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Flexible Strain Sensors for Measuring Contractility Force of Human Stem Cell-Derived Cardiomyocytes

Mendoza, Nicole ;   Carlos, Ruiz ;   Tang, William C. ;   Khine, Michelle

Tags Stem cellsLab-on-ChipMicrofabrication

Contractility assessment of stem cell-derived cardiomyocytes is required to characterize their maturity and functional behavior in vitro. We...

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Formation of Spatially-Defined Heterogeneous ECM-Coated Surfaces Using Microfluidic Patterning with Capillary Stop Valves to Control Cell Adhesion of Stem Cells

Kaneda, Shohei ;   Nakamura, Hiroko ;   Kawada, Jiro ;   Ono, Koichi ;   Fujii, Teruo

Tags Stem cellsTissue engineeringMicrofluidics

A microfluidic device to control condition of cell adhesiveness by the surface coated with two different extracellular matrix (ECM) proteins...

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Hydrogels Containing Aligned Carbon Nanotubes for Fabrication of Muscle Myofibers and Cardiac Differentiation of Embryoid Bodies

Ahadian, Samad ;   Khademhosseini, Ali

Tags BionanotechnologyTissue engineeringStem cells

Dielectrophoresis (DEP) method was introduced for the fabrication of methacrylated gelatin (GelMA)-aligned carbon nanotube (CNT) gels with...

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In Situ iPSC Reprogramming by Non-Viral Chitosan-Based Assembly

Mikhailov, Andrey ;   Saotome, Kousaku ;   Matsushita, Akira ;   Sankai, Yoshiyuki

Tags NanotechnologyStem cellsRegenerative medicine

Here we are demonstrating the assembly from the set of chitosan-based functional materials with defined nano- and macro-properties into...

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Innervation of 3D Printed Biological Machines

Cvetkovic, Caroline ;   Swetenburg, Raymond ;   Rich, Max H ;   Kong, Hyunjoon ;   Stice, Steven L ;   Bashir, Rashid

Tags Tissue engineeringBionanotechnologyStem cells

We report the development of a skeletal muscle powered biological machine (?bio-bot?) capable of biomimetic and directional locomotion, as well...

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Microfluidic Devices for Oxygen Control

Eddington, David

Tags MicrofluidicsStem cells

We have developed a suite of tools to control oxygen concentrations in mammalian cell cultures and tissues. These devices leverage the innate...

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Microphysiological Systems of Cardiac and Tumor Tissue Derived from Induced Pluripotent Stem Cells

George, Steven

Tags Tissue engineeringBioMEMSStem cells

Cancer remains a leading cause of mortality in the United States, and world wide. There remains a need to develop new therapeutic options....

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Microplatform to Identify Drug-Induced Cardiotoxicity in IPS-Derived Cardiomyocytes with Bright-Field Imaging and Machine Learning

Lee, Eugene ;   Kurokawa, Yosuke ;   George, Steven ;   Khine, Michelle

Tags Stem cellsTissue engineeringBionanotechnology

Current drug screening methods are ineffective at detecting drug-induced cardiotoxicity. Here we present a detection method that utilizes...

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Multi-Scale Topographical Patterned Substrates for Promoting Differentiation of Human Neural Stem Cells

Yang, Kisuk ;   Jung, Hyunjung ;   Lee, Hak-Rae ;   Bang, Joona ;   Im, Sung Gap ;   Cho, Seung-Woo

Tags NanotechnologyStem cellsTissue engineering

Self-renewal and differentiation of human neural stem cells (hNSCs) can be controlled by surface topography of culture substrates. In this...

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Physical Phenotyping of Single-Cells for Biomedicine

Di Carlo, Dino

Tags MicrofluidicsStem cellsDiagnostics

Physical properties of cells can provide integrative and quantitative information about various disease states. I will discuss a range of...

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