Comparative Transfection of DNA by AuPAMAM Nanoparticles

Figueroa, Elizabeth ;   Yan, Stepehn ;   Chamberlain-Simon, Nicolette ;   Chen, Allen ;   Drezek, Rebekah

Tags NanotechnologyBionanotechnologyNanomedicine

In this study, we decipher differences in gene delivery by cationic gold-polyamidoamine nanoparticle (AuPAMAM) vectors in easy- and...

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Development of Nanodiamond-Based Platform for Enhanced Cancer Stem Cell Therapy and Cancer Imaging

Wang, Xin ;   Moore, Laura ;   Ho, Dean ;   Chow, Edward

Tags NanomedicineBionanotechnologyNanotechnology

Cancers are often composed of heterogenous tumor cell populations. It is evident now that for many cancers, a specific subpopulation of...

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Diamond-Based Nanomedicine for Cancer Treatment and Imaging

Ho, Dean

Tags Nanomedicine

Nanodiamonds have emerged as promising agents for drug delivery and imaging due to their unique surface properties....

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Formation of Oxidative DNA Damage Corresponds to the Long Term Survival of Human Cells Treated with Nanosilver

Kapka-Skrzypczak, Lucyna ;   Gradzka, Iwona ;   Bartlomiejczyk, Teresa ;   Chwastowska, Jadwiga ;   Sommer, Sylwester ;   Grzelak, Agnieszka ;   Zuberek, Mariusz ;   Lankoff, Anna ;   Wojewódzka, Maria ;   Kruszewski, Marcin

Tags NanomedicineGlobal healthBionanotechnology

A clonogenic potential of 3 human cell lines, HepG2, HT29 and A549, treated with bare 20 nm or 200 nm silver nanoparticles (AgNPs) was...

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Gold Nanoparticle-Mediated Delivery of Antigen and Adjuvant Improves Immune Response Resulting in Anti-Tumor Effects in Vivo

Mattos Almeida, Joao Paulo ;   Lin, Adam ;   Figueroa, Elizabeth ;   Reiser, Emily ;   Foster, Aaron ;   Drezek, Rebekah

Tags NanomedicineBionanotechnologyNanotechnology

Gold nanoparticles (AuNPs) facilitate the delivery of the peptide antigen ovalbumin (OVA) and the CpG adjuvant to improve the...

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Gold Nanoparticles for Targeted Oral Cancer Therapy In-Vivo Evaluation of Hepatotoxicity before Translation

Abdellatif, Omar ;   Saleh, Hazem ;   Salah, Taher ;   Elshazly, Mohamed Osama ;   Khalil, Adel ;   Raafat, Alaa

Tags NanomedicineBionanotechnologyNanotechnology

Gold nanoparticles (GNPs) possess promising potential for curing cancer via photothermal therapy. However, their safety must be addressed...

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Hybrid Bio-Synthetic Gene Therapy Vector Development for Next Generation Vaccines

Jones, Charles ;   Ravikrishnan, Anitha ;   Chen, Mingfu ;   Reddinger, Ryan ;   Ahmadi, Mahmoud ;   Rane, Snehal ;   Hakansson, Anders ;   Pfeifer, Blaine

Tags BionanotechnologyNanomedicineGlobal health

Vaccination is a powerful means of pre-empting or treating disease. The process depends on successful recognition of a foreign entity (an...

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Limiting the Secondary Phase of Contusive Spinal Cord Injury Using Conjugated Iron Oxide Nanoparticles

All, Angelo

Tags Nanomedicine

Abstract? Spinal cord injury (SCI) severely limits mobility and leads to a poor quality of life with no treatment options. Secondary phase of...

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Lipid Multilayer Nanostructures on Surfaces as Bioinspired Compartments

Lenhert, Steven

Tags BionanotechnologyNanotechnologyNanomedicine

Lipid bilayer membranes form the basis of compartments such as cells and organelles in biology. Fabrication of lipid multilayer nanostructures...

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Magnetic Guidance of Temozolomide-Containing Particles through Brain Tissue

Mair, Lamar ;   Weinberg, Irving ;   Nacev, Alek ;   Stepanov, Pavel ;   Urdaneta, Mario ;   Hilaman, Ryan ;   Himmelfarb, Stephanie ;   Diaz-Caballero, Elena ;   Rigla, Juan Pablo ;   Kulkarni, Sandip ;   Shapiro, Benjamin

Tags NanomedicineNanotechnologyMicrofabrication

Temozolomide (TMZ) is an FDA approved drug for treatment of brain tumors. Encapsulation of this drug in a magnetic nanoparticle carrier has...

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Maximizing the Intracellular Delivery of Spherical Nucleic Acids by Engineering Oligonucleotide Sequence

Narayan, Suguna ;   Choi, Chung Hang J ;   Hao, Liangliang ;   Calabrese, Colin ;   Mirkin, Chad

Tags BionanotechnologyNanotechnologyNanomedicine

Spherical nucleic acids (SNAs), consisting of densely packed, highly oriented oligonucleotides attached to the surface of nanoparticles, are...

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Microfluidic, Multifunctional, Multilayer, Monodisperse Microbubbles

Lee, Abraham ;   Hettiarachchi, Kanaka ;   Bardin, David ;   Shih, Roger

Tags MicrofluidicsNanomedicineDiagnostics

In this talk I will review my lab's development of microfluidic technology for multilayer vesicles (MVs), focusing on gaseous-cored microbubbles....

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Nanoscale Neuromorphic Circuit to Model DemylinationRemyelination

Yue, Kun ;   Parker, Alice

Tags NanotechnologyBionanotechnologyNanomedicine

We demonstrated Neuromorphic circuit models for Demyelinated and Remyelinated axons. Nanoscale devices including nanoresistors and...

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Sirna-Based Spherical Nucleic Acid Nanoparticle Conjugates Increase the Rate of Wound Healing in Subjects with Type 2 Diabetes

Randeria, Pratik ;   Paller, Amy S. ;   Mirkin, Chad

Tags BionanotechnologyNanomedicineNanotechnology

Diabetic patients often suffer from impaired wound healing, which can develop into non-healing diabetic ulcers, facilitate bacterial infections,...

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Stickyflares: A Platform for the Quantification and Spatio-Temporal Tracking of RNA in Live Cells

Briley, William ;   Mirkin, Chad

Tags BionanotechnologyNanotechnologyNanomedicine

We report a novel gold nanoparticle-DNA conjugate, termed the Stickyflare, which provides a platform for facile quantification of relative RNA...

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Targeted Magnetic Resonance Imaging through Nanodiamonds

Moore, Laura ;   Towsend, Taryn R. ;   Meade, Thomas J. ;   Ho, Dean

Tags NanomedicineNanotechnologyDiagnostics

Steroid hormone receptors play a key role in the prognosis and treatment of a variety of cancers including breast, ovarian and prostate....

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Targeting Survivin: A SPION-Based Approach to Cancer Diagnostics and Therapy

Despeaux, Emily ;   Talbott, Siera ;   Gannett, Peter ;   Pisane, Kelly ;   Seehra, Mohindar ;   Carroll, R. Lloyd

Tags NanomedicineDiagnosticsBionanotechnology

Magnetic nanoparticles, including superparamagnetic iron oxide nanoparticles (SPION), have the potential to significantly improve the diagnosis...

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The Axonal Spatial-Temporal Reactive Assembly (astra)

Morgera, Salvatore Domenic

Tags NanotechnologyMicrofabricationNanomedicine

An emerging intersection of the neuroengineering of nerve fiber (axon) tracts/bundles and communications networks is described. At the...

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The Expression of NF-kB Related Genes in Response to Nanosilver is Cell Type Specific and Related to the Basal Activity of NF-kB

Kruszewski, Marcin ;   Stepkowski, Tomasz M. ;   Brzóska, Kamil ;   Kapka-Skrzypczak, Lucyna

Tags NanomedicineGlobal healthBionanotechnology

Silver nanoparticles (AgNPs) are widely used in medicine and industry, but the recent evidence for their cytotoxicity rise a concern about...

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Top-Down Designing and Fabrication of Metal Nanostructures for Plasmonics-Assisted Biomedical Sensing Applications

Chang, Chieh-feng ;   Walavalkar, Sameer ;   Marin, Brandon ;   Scherer, Axel

Tags NanotechnologyBionanotechnologyNanomedicine

Traditionally plasmonics was approached with bottom-up synthesis or time-consuming techniques like focused ion beam (FIB). We report an...

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Towards a Diffusion-Based Microfluidic Device for Isolation of Cell-Derived Microparticles

Cherré, Solène ;   Olsen, Mark ;   Noemi, Rozlosnik

Tags MicrofluidicsDiagnosticsNanomedicine

Cell-derived microparticles (MPs) have been proposed as novel diagnostics biomarkers for a wide range of diseases. However instruments and...

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