A Microfluidic Platform for Quantitative Analysis of Cancer Angiogenesis and Intravasation

Lee, Hyunjae ;   Park, Woohyun ;   Ryu, Hyunryul ;   Jeon, Noo Li

Tags BioMEMSLab-on-Chip

Understanding the mechanism behind cancer metastasis is a major challenge in cancer biology. Several in vitro models have been developed to...

Read More Download this Paper

An Image Reconstruction Method Using Singular Value Decomposition for Magnetic Particle Imaging

Shimizu, Shota ;   Tsuchiya, Hiroki ;   takagi, tomoyuki ;   Hatsuda, Tomoki ;   Noguchi, Tomoaki ;   Ishihara, Yasutoshi

Tags DiagnosticsNanotechnologyMicrofluidics

Magnetic particle imaging is a medical imaging technology suitable for noninvasive diagnostics. However, the image resolution was degraded due...

Read More Download this Paper

An Integrated Bubble Trap for Continuous Removal of Gas Bubbles from Microfluidic Chips

Dokmeci, Mehmet R. ;   Zhang, Yu Shrike ;   Chae, Sukyoung ;   Polini, Alessandro ;   Khademhosseini, Ali

Tags BioMEMSLab-on-Chip

In this paper we present a miniature bubble trap for efficient removal of bubbles from microfluidic reactors. The new bubble trap has a 10 mm...

Read More Download this Paper

An iPS-derived, Vascularized Cardiac Tissue as an in vitro Drug Screening Platform

Kurokawa, Yosuke ;   Tran, David ;   Moya, Monica ;   Sobrino, Agua, Agua ;   Alonzo, Luis ;   Tu, Christina ;   Lock, Leslie ;   Hughes, Christopher ;   Conklin, Bruce ;   George, Steven

Tags Tissue engineeringStem cellsMicrofluidics

Drug attrition due to cardiac toxicity is prevalent, and a better preclinical screening tool is required in order to solve this issue. Here we...

Read More Download this Paper

Continuous Monitoring of Bacteria in Drinking Water

Svendsen, Winnie E ;   Bertelsen, Christian Vinther ;   Skands, Gustav ;   Dimaki, Maria ;   Clausen, Casper Hyttel

Tags NanotechnologyGlobal healthMicrofluidics

Real-time continuous monitoring of bacteria concentrations in drinking water is of great importance in drinking water management. The methods...

Read More Download this Paper

Droplet Libraries for Digital PCR with Improved Dynamic Range

Kaminski, Tomasz S. ;   Postek, Witold ;   Debski, Pawel R. ;   Garstecki, Piotr

Tags MicrofluidicsLab-on-ChipDiagnostics

This paper reports a microfluidic system that i) generate a sequence of 20 microliter droplets of a 2-fold dilution of DNA concentration ii)...

Read More Download this Paper

Formation of Spatially-Defined Heterogeneous ECM-Coated Surfaces Using Microfluidic Patterning with Capillary Stop Valves to Control Cell Adhesion of Stem Cells

Kaneda, Shohei ;   Nakamura, Hiroko ;   Kawada, Jiro ;   Ono, Koichi ;   Fujii, Teruo

Tags Stem cellsTissue engineeringMicrofluidics

A microfluidic device to control condition of cell adhesiveness by the surface coated with two different extracellular matrix (ECM) proteins...

Read More Download this Paper

High Throughout, Microprinting of Tumor Spheroids for Anti-Cancer Drug Screening

Stephanie, Lemmo ;   Atefi, Ehsan ;   Tavana, Hossein

Tags Tissue engineeringMicrofluidicsBionanotechnology

We report a new approach to generating tumor spheroids using a polymeric aqueous two-phase system (ATPS). Cancer cells are confined in an...

Read More Download this Paper

HUVEC-MSC Interactions in the Initiation of Capillary Network Formation

Uwamori, Hiroyuki ;   Sudo, Ryo

Tags Tissue engineeringBioMEMSMicrofluidics

There is a demand for construction of functional capillaries in the field of tissue engineering. However, the mechanism of such capillary...

Read More Download this Paper

Microfluidic Neuron: A Neuromimetic Approach to Interact with Biological Neurons

Levi, Timothee ;   Araki, Ayako ;   Fujii, Teruo

Tags MicrofluidicsBioMEMSLab-on-Chip

This article deals with the design of a new microfluidic device which reproduces the electrical behavior of one biological neuron. The main goal...

Read More Download this Paper

Microfluidic Neuronal Cell-Culture Device for Continuous Measurement of Neurotransmitters Upon Stimulations

Talaei, Sara ;   Simi, Alessandro ;   Bosca, Alessandro ;   Berdondini, Luca ;   van der Wal, Peter D. ;   de Rooij, Nico F.

Tags BioMEMSLab-on-ChipMicrofluidics

We present a compartmentalized neuronal cell-culture device that provides the possibility of obtaining samples directly from the synaptic...

Read More Download this Paper

Microfluidic Single Sperm Entrapment and Analysis

de Wagenaar, Bjorn ;   Berendsen, Jorien ;   Huisintveld, Nik ;   Olthuis, Wouter ;   van den Berg, Albert ;   Segerink, Loes Irene

Tags MicrofluidicsBionanotechnologyDiagnostics

This abstract describes the hydrodynamic trapping of single spermatozoa in a microfluidic platform, allowing the investigation of sperm...

Read More Download this Paper

Microfluidic, Multifunctional, Multilayer, Monodisperse Microbubbles

Lee, Abraham ;   Hettiarachchi, Kanaka ;   Bardin, David ;   Shih, Roger

Tags MicrofluidicsNanomedicineDiagnostics

In this talk I will review my lab's development of microfluidic technology for multilayer vesicles (MVs), focusing on gaseous-cored microbubbles....

Read More Download this Paper

Microphysiological Systems to Study Metastasis at High Spatiotemporal Resolution

Shirure, Venktesh ;   Waterman, Marian ;   George, Steven

Tags Tissue engineeringLab-on-ChipMicrofluidics

Metastasis, the most devastating consequence of cancer, remains challenging to treat, and better understanding of the metastatic process is...

Read More Download this Paper

MIDAS – MIcrofluidics Detection Using Acoustic Spectroscopy

Sherman, Samuel ;   Anstett, Florent ;   Napoli, Maria ;   Bamieh, Bassam ;   Turner, Kimberly ;   Pennathur, Sumita

Tags BioMEMSMicrofluidicsLab-on-Chip

We propose a novel, microfluidics-based device that senses biomolecular markers and viscoelastic properties of relevant bodily fluids by...

Read More Download this Paper

Super-Resolved Micro-Vascular Imaging Using Microbubbles and Machine Learning

Christensen-Jeffries, Kirsten ;   Schirmer, Markus D ;   Browning, Richard ;   Tang, Meng-Xing ;   Dunsby, Christopher ;   Aljabar, Paul ;   Eckersley, Robert John

Tags MicrofluidicsDiagnostics

Recent developments in sub-diffraction ultrasound (US) imaging using clinical US systems has shown the potential to resolve structures on the...

Read More Download this Paper

The Development of an Optopiezoelectric Micropump for Microfluidic Applications

Wang, Hsin-Hu ;   Lee, Chih-Kung ;   Hsu, Yu-Hsiang

Tags MicrofluidicsMicrofabricationLab-on-Chip

In this paper, we present a polymer-based piezoelectric micropump that can be selectively activated and controlled by a masked light source....

Read More Download this Paper

Three Dimensional Microfluidic Model to Investigate Synergism of Biomechanical and Biochemical Factors on Angiogenic Sprouting

Chung, Minhwan ;   Ahn, Jungho ;   Kim, Sudong ;   Lee, Hyunjae ;   Jeon, Noo Li

Tags BioMEMSTissue engineering

Interstitial fluid is composing more than 20 % of our body fluid, making creeping but constant flow called interstitial flow (IF) through the...

Read More Download this Paper

Towards a Diffusion-Based Microfluidic Device for Isolation of Cell-Derived Microparticles

Cherré, Solène ;   Olsen, Mark ;   Noemi, Rozlosnik

Tags MicrofluidicsDiagnosticsNanomedicine

Cell-derived microparticles (MPs) have been proposed as novel diagnostics biomarkers for a wide range of diseases. However instruments and...

Read More Download this Paper