3D-Bioengineering of the Conventional Outflow Tract as Model for High-Throughput Drug Screening

Cula, Dautriche ;   Susan, Sharfstein ;   Xie, Yubing ;   Bergkvist, Magnus ;   Kerr, Matthew ;   Szymanski, Dennis ;   Danias, John ;   Stamer, W. D.

Tags Tissue engineeringRegenerative medicineMicrofabrication

Glaucoma remains the leading cause of irreversible blindness worldwide. Glaucoma is characterized by chronic degeneration of axons of the...

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A Fabrication Platform for Stretchable Electronic Medical Devices

Savov, Angel ;   Khoshfetrat Pakazad, Saeed ;   Joshi, Shivani ;   Henneken, Vincent ;   Dekker, Ronald

Tags MicrofabricationBioMEMSLab-on-Chip

A CMOS compatible post-processing technology for the fabrication of high-density stretchable electronic circuits is demonstrated. The...

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A New Competitive Fluorescence Immune-Assay for Detection of Listeria Monocytogenes

Lacroix, Monique ;   D'Auria, Sabato

Tags Diagnostics

A new competitive immune assay has been designed using a specific monoclonal antibody (anti-p60 IgG) labeled with a fluorophore. A specific and...

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A Separated Carbon Nanotube Synapse

Lee, Rebecca K. ;   Zhang, Jialu ;   Parker, Alice ;   Zhou, Chongwu

Tags NanotechnologyBionanotechnology

A simple biomimetic synapse circuit has been fabricated using separated carbon nanotube transistors. Experimental results show that the...

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All-Polymer, High-Aspect-Ratio, Soft Lithography

Bubendorfer, Andrea ;   Best, Andrew ;   Arnold, William Michael

Tags MicrofabricationLab-on-ChipBioMEMS

Microfluidic ?chips? are commonly produced by molding or embossing from master structures: the masters need to be able to withstand many...

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An Optically Transparent Micro-Ring Ultrasonic Detection Enables Isometric Multimodal Photoacoustic Microscopy

Dong, Biqin ;   Li, Hao ;   Zhang, Hao ;   Sun, Cheng

Tags NanotechnologyMicrofabricationDiagnostics

A cover-slip type transparent optical ultrasonic detector based on a polymeric micro-ring resonator was developed for achieving optical...

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Assessments of T-Nanowire Transistor Assay for Clinical Diabetic Nephropathy

Mao, Yufei ;   Shin, Kyeong-Sik ;   Nicholas, Susanne ;   Chui, Chi On

Tags DiagnosticsLab-on-ChipBionanotechnology

For the first time, we assessed the amplifying T-nanowire transistor assay in quantitating a key diabetic kidney disease (DKD) urinary...

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Brain Stem Cell Interaction with Nanostructured Poly-Si/Pt Surfaces

Bérces, Zsófia ;   Horváth, Ágoston Csaba ;   Jády, Attila Gyula ;   Pongrácz, Anita ;   Madarász, Emília ;   Fekete, Zoltán

Tags NanotechnologyBionanotechnologyMicrofabrication

In this work, we investigate the biocompatibility of platinized poly-silicon surfaces with different nanoscale textures using NE-4C cell culture....

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Comparative Transfection of DNA by AuPAMAM Nanoparticles

Figueroa, Elizabeth ;   Yan, Stepehn ;   Chamberlain-Simon, Nicolette ;   Chen, Allen ;   Drezek, Rebekah

Tags NanotechnologyBionanotechnologyNanomedicine

In this study, we decipher differences in gene delivery by cationic gold-polyamidoamine nanoparticle (AuPAMAM) vectors in easy- and...

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Cytodetachment Technique Using Ultrasonic Vibration

Kurashina, Yuta ;   Takemura, Kenjiro ;   Miyata, Shogo ;   Komotori, Jun ;   Koyama, Tadayoshi

Tags BionanotechnologyMicrofabricationTissue engineering

Ultrasonic vibration is often used in tissue engineering, for example, to provide effective mechanical stimuli for cell growth. This study aims...

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Densification of Carbon Nanotubes via Uniaxial Shrinking

Kim, Joshua ;   Khine, Michelle

Tags Nanotechnology

Carbon nanotubes (CNTs) have become a widely studied nanoscale material ever since their discovery in 1991, and have been implemented in many...

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Development of Nanodiamond-Based Platform for Enhanced Cancer Stem Cell Therapy and Cancer Imaging

Wang, Xin ;   Moore, Laura ;   Ho, Dean ;   Chow, Edward

Tags NanomedicineBionanotechnologyNanotechnology

Cancers are often composed of heterogenous tumor cell populations. It is evident now that for many cancers, a specific subpopulation of...

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Effect on Invasive Capacity of Cancer Cell Spheroid Co-Cultured with Vascular Endothelial Cell Network Using In Vitro 3D Patterning Model

Yamamoto, Shuhei ;   Okochi, Mina ;   Honda, Hiroyuki

Tags BionanotechnologyTissue engineering

In vitro three dimensional (3D) cancer models were developed to observe the invasive capacity of cancer cell spheroids co-cultured with the...

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Elasticity Tunable Hybrid Hydrogels Using Light Irradiation

Yanagawa, Fumiki ;   Mizutani, Takeomi ;   Sugiura, Shinji ;   Takagi, Toshiyuki ;   Sumaru, Kimio ;   Kanamori, Toshiyuki

Tags Tissue engineeringMicrofabrication

This paper reports a novel technique to synthesize elasticity tunable hybrid hydrogels with an activated-ester-type photocleavable...

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Encapusulation of Natural Synthesized Novel Nutraceutical Biomolecules

Kermasha, Selim ;   Aziz, Sarya

Tags NanotechnologyBionanotechnologyGlobal health

There has been growing evidence supporting the nutritional benefits of long-chain n-3-polyunsaturated fatty acids (ω-3-PUFAs), in...

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Experimental Analysis of Temperature Dependent Ultrasound Microbeam Trapping Mechanism of Biocompatible Microdroplet by Dual Element Focused Ultrasonic Transducer

Hwang, Jae Youn ;   Lee, Jungwoo

Tags BionanotechnologyBioMEMSMicrofabrication

An experimental study is carried out by using a 20/40 MHz LiNbO3 dual element focused transducer to examine the quantitative relation...

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Flexible, Printable, and Biocompatible CNT-Based Conductive Ink for Fabrication of Supercapacitors and Biosensors

Shin, Su-Ryon ;   Farzad, Razieh ;   Monaharan, Vijian ;   Tamayol, Ali ;   Zhang, Yu Shrike ;   Duck jin, Kim ;   Annabi, Nasim ;   Comotto, Mattia ;   Akbari, Mohsen ;   Dokmeci, Mehmet R. ;   Khademhosseini, Ali

Tags NanotechnologyBionanotechnologyMicrofabrication

ABSTRACT--Multifunctional carbon nanotubes (CNTs) composite materials are currently of considerable interest in fabrication of flexible...

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Formation of Oxidative DNA Damage Corresponds to the Long Term Survival of Human Cells Treated with Nanosilver

Kapka-Skrzypczak, Lucyna ;   Gradzka, Iwona ;   Bartlomiejczyk, Teresa ;   Chwastowska, Jadwiga ;   Sommer, Sylwester ;   Grzelak, Agnieszka ;   Zuberek, Mariusz ;   Lankoff, Anna ;   Wojewódzka, Maria ;   Kruszewski, Marcin

Tags NanomedicineGlobal healthBionanotechnology

A clonogenic potential of 3 human cell lines, HepG2, HT29 and A549, treated with bare 20 nm or 200 nm silver nanoparticles (AgNPs) was...

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Hybrid Biological-Biomaterial Gene Delivery Vector Development and Dual Engineering Potential

Pfeifer, Blaine ;   Jones, Charles ;   Hakansson, Anders

Tags Global health

Genetic vaccines offer a treatment opportunity based upon successful gene delivery to specific immune cell modulators. Driving the process is...

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In Situ iPSC Reprogramming by Non-Viral Chitosan-Based Assembly

Mikhailov, Andrey ;   Saotome, Kousaku ;   Matsushita, Akira ;   Sankai, Yoshiyuki

Tags NanotechnologyStem cellsRegenerative medicine

Here we are demonstrating the assembly from the set of chitosan-based functional materials with defined nano- and macro-properties into...

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Indirect Fabrication of Three-Dimensional Hydrogel Constructs for Tissue Engineering Applications

Pimentel Carletto, Rodrigo ;   Muhammad, Haseena Bashir ;   Wolff, Anders ;   Dufva, Martin ;   Emnéus, Jenny ;   Okkels, Fridolin

Tags Tissue engineeringMicrofabrication

We present a three-dimensional (3D) tissue-engineering construct, realized using an indirect fabrication technique. By using fused deposition...

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Innervation of 3D Printed Biological Machines

Cvetkovic, Caroline ;   Swetenburg, Raymond ;   Rich, Max H ;   Kong, Hyunjoon ;   Stice, Steven L ;   Bashir, Rashid

Tags Tissue engineeringBionanotechnologyStem cells

We report the development of a skeletal muscle powered biological machine (?bio-bot?) capable of biomimetic and directional locomotion, as well...

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Lipid Multilayer Nanostructures on Surfaces as Bioinspired Compartments

Lenhert, Steven

Tags BionanotechnologyNanotechnologyNanomedicine

Lipid bilayer membranes form the basis of compartments such as cells and organelles in biology. Fabrication of lipid multilayer nanostructures...

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Low Percolation Threshold Conductive POSS-PCL/Graphene Nanocomposite Polymer; Application for Nerve Regeneration

Nezakati, Toktam ;   Seifalian, Alexander

Tags BionanotechnologyRegenerative medicine

A low percolation threshold electrically conductive polymer using polyhedral oligomeric silsesquioxane (POSS) nanocage incorporated into a...

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Low-Dosages of Zeolite 13X Produce a Bimodal Effect on Breast Cancer Cells: Geno-Oxidative Damage and Reduction of Lipid Peroxidation

Malara, Natalia, Maria ;   Tiriolo, Raffaele ;   Trunzo, Valentina ;   Pullano, Salvatore A. ;   Elisabetta, Dattola ;   Paola, Failla ;   di Fabrizio, Enzo ;   Mollace, Vincenzo ;   Fiorillo, Antonino S.

Tags DiagnosticsNanotechnology

Zeolite is a nanoporous material possessing excellent properties for application in medical and biological engineering. The effects of low...

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Maximizing the Intracellular Delivery of Spherical Nucleic Acids by Engineering Oligonucleotide Sequence

Narayan, Suguna ;   Choi, Chung Hang J ;   Hao, Liangliang ;   Calabrese, Colin ;   Mirkin, Chad

Tags BionanotechnologyNanotechnologyNanomedicine

Spherical nucleic acids (SNAs), consisting of densely packed, highly oriented oligonucleotides attached to the surface of nanoparticles, are...

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Methacrylated Gelatin Hydrogel Fibers with Micro-Grooves for Tissues Engineering

Ostrovidov, Serge ;   Shi, Xuetao ;   Khademhosseini, Ali

Tags Tissue engineeringMicrofluidicsRegenerative medicine

Fiber shape processed biomaterials have attracted interest from the tissue engineering community due to their versatile processability and...

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Microplatform to Identify Drug-Induced Cardiotoxicity in IPS-Derived Cardiomyocytes with Bright-Field Imaging and Machine Learning

Lee, Eugene ;   Kurokawa, Yosuke ;   George, Steven ;   Khine, Michelle

Tags Stem cellsTissue engineeringBionanotechnology

Current drug screening methods are ineffective at detecting drug-induced cardiotoxicity. Here we present a detection method that utilizes...

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Microvascular-Like Networks Induced Hydrogel Block for Tissue Engineering

Lee, Kwang-Ho ;   Lee, Hayoung

Tags Tissue engineering

Micro-vasularization is a key factor of tissue regeneration, which play important regulatory roles in regenerating tissue. Combination of...

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Multi-Scale Topographical Patterned Substrates for Promoting Differentiation of Human Neural Stem Cells

Yang, Kisuk ;   Jung, Hyunjung ;   Lee, Hak-Rae ;   Bang, Joona ;   Im, Sung Gap ;   Cho, Seung-Woo

Tags NanotechnologyStem cellsTissue engineering

Self-renewal and differentiation of human neural stem cells (hNSCs) can be controlled by surface topography of culture substrates. In this...

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Nanoscale Neuromorphic Circuit to Model DemylinationRemyelination

Yue, Kun ;   Parker, Alice

Tags NanotechnologyBionanotechnologyNanomedicine

We demonstrated Neuromorphic circuit models for Demyelinated and Remyelinated axons. Nanoscale devices including nanoresistors and...

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Needle Microelectrodes for Electromyography Recording from Zebrafish Larvae

Cho, Sung-Joon ;   Nam, Tae-Seung ;   Choi, Seok-Yong ;   Kim, Myoung-Kyu ;   Kim, Sohee

Tags MicrofabricationBionanotechnologyNanotechnology

Electromyography (EMG) is the most effective tool in diagnosing muscular diseases, and it is an essential tool in developing treatment agents...

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Optical Cell Separation from 3D Culture Environment in Photodegradable Hydrogels for Pure Culture Techniques

Tamura, Masato ;   Yanagawa, Fumiki ;   Sugiura, Shinji ;   Takagi, Toshiyuki ;   Sumaru, Kimio ;   Matsui, Hirofumi ;   Kanamori, Toshiyuki

Tags Tissue engineeringDiagnostics

We present a new methodology for optical cell picking in 3D culture environment. In this study, we encapsulated cells in photodegradable...

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Pneumatic and Hydraulic MRI-Compatible Micromanipulator System and Its MRI-Compatibility

Wong, Kahngee ;   Koseki, Yoshihiko ;   Yamauchi, Yasushi

Tags Microfabrication

 This paper presents a micromanipulator system designed for use in magnetic resonance imaging (MRI) environments in order to enable...

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Projection Micro-Stereolithography Apparatus for High-Resolution 3D Patterning of Cells: Applications in Vascular Tissue Engineering

Raman, Ritu ;   Bhaduri, Basanta ;   Shkumatov, Artem ;   Kong, Hyunjoon ;   Popescu, Gabriel ;   Bashir, Rashid

Tags MicrofabricationBionanotechnologyTissue engineering

We have developed a projection micro-stereolithography apparatus (microSLA) capable of patterning cells encapsulated in biocompatible...

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Selective Cell Adhesion to Surface Nanotopography

Liang, Elena ;   Dickson, Mary Nora ;   Yee, Albert

Tags Nanotechnology

In this work, we present the use of nanotopography as a method to control cell adhesion on materials surfaces without chemical surfaces...

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Sirna-Based Spherical Nucleic Acid Nanoparticle Conjugates Increase the Rate of Wound Healing in Subjects with Type 2 Diabetes

Randeria, Pratik ;   Paller, Amy S. ;   Mirkin, Chad

Tags BionanotechnologyNanomedicineNanotechnology

Diabetic patients often suffer from impaired wound healing, which can develop into non-healing diabetic ulcers, facilitate bacterial infections,...

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Stereolithographic Manufacture of Microneedle Patch Arrays for Blood Collection

Faraji Rad, Zahra ;   Davies, Graham ;   Anthony, Carl ;   Prewett, Philip D ;   Nordon, Robert E

Tags MicrofabricationDiagnosticsLab-on-Chip

3D laser lithography is used to manufacture microneedle master molds with optimal geometric designs for collection of subcutaneous capillary...

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Stickyflares: A Platform for the Quantification and Spatio-Temporal Tracking of RNA in Live Cells

Briley, William ;   Mirkin, Chad

Tags BionanotechnologyNanotechnologyNanomedicine

We report a novel gold nanoparticle-DNA conjugate, termed the Stickyflare, which provides a platform for facile quantification of relative RNA...

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Targeted Magnetic Resonance Imaging through Nanodiamonds

Moore, Laura ;   Towsend, Taryn R. ;   Meade, Thomas J. ;   Ho, Dean

Tags NanomedicineNanotechnologyDiagnostics

Steroid hormone receptors play a key role in the prognosis and treatment of a variety of cancers including breast, ovarian and prostate....

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Targeting Survivin: A SPION-Based Approach to Cancer Diagnostics and Therapy

Despeaux, Emily ;   Talbott, Siera ;   Gannett, Peter ;   Pisane, Kelly ;   Seehra, Mohindar ;   Carroll, R. Lloyd

Tags NanomedicineDiagnosticsBionanotechnology

Magnetic nanoparticles, including superparamagnetic iron oxide nanoparticles (SPION), have the potential to significantly improve the diagnosis...

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Temperature Dependence of Scanning Angle Frequency Response of Electrostatic Comb-Actuated Micro-Scanner

Ikeda, Kentaro ;   Okazaki, Koji ;   Ishikawa, Noriaki ;   Sawada, Renshi

Tags BioMEMSNanotechnology

We have investigated the temperature dependence of scanning angle frequency response of the electrostatic comb-actuated micro-scanner...

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The Axonal Spatial-Temporal Reactive Assembly (astra)

Morgera, Salvatore Domenic

Tags NanotechnologyMicrofabricationNanomedicine

An emerging intersection of the neuroengineering of nerve fiber (axon) tracts/bundles and communications networks is described. At the...

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The Expression of NF-kB Related Genes in Response to Nanosilver is Cell Type Specific and Related to the Basal Activity of NF-kB

Kruszewski, Marcin ;   Stepkowski, Tomasz M. ;   Brzóska, Kamil ;   Kapka-Skrzypczak, Lucyna

Tags NanomedicineGlobal healthBionanotechnology

Silver nanoparticles (AgNPs) are widely used in medicine and industry, but the recent evidence for their cytotoxicity rise a concern about...

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The New Evaluation Method of Intestinal Absorption Used by Spectroscopic Imaging in Animal Production Science

Takagi, Ryo ;   Matsumoto, Yoshiki

Tags Diagnostics

Morphological aspects of gastrointestinal tract were well analyzed the response of digestive juice and applied in the feed supplement...

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Three-Dimensional Textured Graphene Bioelectronics

Wang, Michael Cai ;   Choi, Jonghyun ;   Yong, Keong ;   Ashraf, Ali ;   Nam, SungWoo

Tags NanotechnologyBionanotechnologyDiagnostics

Superb electromechanical properties of graphene, where large elastic deformation is achievable without significant perturbation of electrical...

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Top-Down Designing and Fabrication of Metal Nanostructures for Plasmonics-Assisted Biomedical Sensing Applications

Chang, Chieh-feng ;   Walavalkar, Sameer ;   Marin, Brandon ;   Scherer, Axel

Tags NanotechnologyBionanotechnologyNanomedicine

Traditionally plasmonics was approached with bottom-up synthesis or time-consuming techniques like focused ion beam (FIB). We report an...

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Towards a Scalable Biomimetic Antibacterial Coating

Dickson, Mary Nora ;   Liang, Elena ;   Vollereaux, Nicolas ;   Yee, Albert

Tags NanotechnologyBionanotechnologyGlobal health

This work presents proof of concept that a biomimetic nanostructured surface can kill bacteria upon adhesion, without the use of chemical...

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Wireless Power Transfer System for Endoscopic Capsule Robot

Park, Wanjoo ;   Kim, Laehyun

Tags Diagnostics

Robotic capsule endoscopy is a revolutionary procedure for examining the entire gastrointestinal tract by active locomotion of the capsule...

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