A Magnetic Microparticle Capture and Liposome-Based Impedance Sensing Device for Detection of Viruses in Blood

Damhorst, Gregory ;   Sobieraj, Magdalena ;   Chaves, Rodrigo ;   Kooiman, Jonathan ;   Smith, Cartney ;   Kong, Hyunjoon ;   Bashir, Rashid

Low-cost, rapid detection of viruses in blood at the point-of-care remains a challenge and an unmet global need in the management of a number of infectious diseases. We are developing a microfluidic platform with affinity-capture, magnetic separation, and impedance sensing components for detection of viruses from whole blood. In particular, Human Immunodeficiency Virus (HIV), the virus that causes Acquired Immune Deficiency Syndrome (AIDS), affects over 35 million people worldwide and is among the greatest infectious disease burdens in remote and resource-limited areas. Here we report progress toward a microfluidic device which aims for quantitation of HIV from whole blood.