Microfluidic Neuronal Cell-Culture Device for Continuous Measurement of Neurotransmitters Upon Stimulations
Talaei, Sara ; Simi, Alessandro ; Bosca, Alessandro ; Berdondini, Luca ; van der Wal, Peter D. ; de Rooij, Nico F.
We present a compartmentalized neuronal cell-culture device that provides the possibility of obtaining samples directly from the synaptic clefts. The samples are transferred to a microfluidic sensing unit designed for continuous measurement of neurotransmitters. The special design of the culture device also enables stimulating the cells both electrically and chemically.