Detection of PCR Amplification by Top-Down Silicon Nanowires Field Effect Transistors

Accastelli, Enrico ;   Spiga, Fabio Mario ;   Ernst, Thomas ;   Guiducci, Carlotta

We propose the implementation of PCR system measuring DNA amplification by using top-down, CMOS compatible SiNWs. The DNA amplification cycles induce a progressive change of the pH of the solution that is observed by measuring the related change of the SiNW drain current.