Magnetic Guidance of Temozolomide-Containing Particles through Brain Tissue

Mair, Lamar ;   Weinberg, Irving ;   Nacev, Alek ;   Stepanov, Pavel ;   Urdaneta, Mario ;   Hilaman, Ryan ;   Himmelfarb, Stephanie ;   Diaz-Caballero, Elena ;   Rigla, Juan Pablo ;   Kulkarni, Sandip ;   Shapiro, Benjamin

Temozolomide (TMZ) is an FDA approved drug for treatment of brain tumors. Encapsulation of this drug in a magnetic nanoparticle carrier has the potential to improve delivery of the drug to the brain tumor under image guidance. We present TMZ-containing magnetic particles that can be magnetically guided through rat brain tissue.