Magnetic Guidance of Temozolomide-Containing Particles through Brain Tissue
Mair, Lamar ; Weinberg, Irving ; Nacev, Alek ; Stepanov, Pavel ; Urdaneta, Mario ; Hilaman, Ryan ; Himmelfarb, Stephanie ; Diaz-Caballero, Elena ; Rigla, Juan Pablo ; Kulkarni, Sandip ; Shapiro, Benjamin
Temozolomide (TMZ) is an FDA approved drug for treatment of brain tumors. Encapsulation of this drug in a magnetic nanoparticle carrier has the potential to improve delivery of the drug to the brain tumor under image guidance. We present TMZ-containing magnetic particles that can be magnetically guided through rat brain tissue.