Gold Nanoparticles for Targeted Oral Cancer Therapy In-Vivo Evaluation of Hepatotoxicity before Translation

Abdellatif, Omar ;   Saleh, Hazem ;   Salah, Taher ;   Elshazly, Mohamed Osama ;   Khalil, Adel ;   Raafat, Alaa

Gold nanoparticles (GNPs) possess promising potential for curing cancer via photothermal therapy. However, their safety must be addressed before translation. In this paper,we evaluate the hepatotoxic effect of systemic and intra tumor injection of gold nanospheres conjugated with anti-epidermal growth factor receptor anti-EGFR antibody in hamster model bearing chemically induced cheek pouch tumor.