Gold Nanoparticle-Mediated Delivery of Antigen and Adjuvant Improves Immune Response Resulting in Anti-Tumor Effects in Vivo

Mattos Almeida, Joao Paulo ;   Lin, Adam ;   Figueroa, Elizabeth ;   Reiser, Emily ;   Foster, Aaron ;   Drezek, Rebekah

Gold nanoparticles (AuNPs) facilitate the delivery of the peptide antigen ovalbumin (OVA) and the CpG adjuvant to improve the antigen-specific immune response, which limits tumor growth and improves survival outcomes in prophylactic and therapeutic in vivo tumor models.