In Situ iPSC Reprogramming by Non-Viral Chitosan-Based Assembly

Mikhailov, Andrey ;   Saotome, Kousaku ;   Matsushita, Akira ;   Sankai, Yoshiyuki

Here we are demonstrating the assembly from the set of chitosan-based functional materials with defined nano- and macro-properties into implantable structures. These structures are well tolerated on both cell and tissue levels, slowly releasing their macromolecular cargo, traceable by MRI, mechanically sound, and able to initialize cell reprogramming both in vitro and in vivo.