Targeted Magnetic Resonance Imaging through Nanodiamonds

Moore, Laura ;   Towsend, Taryn R. ;   Meade, Thomas J. ;   Ho, Dean

Steroid hormone receptors play a key role in the prognosis and treatment of a variety of cancers including breast, ovarian and prostate. This work demonstrates that nanodiamonds are capable of labeling cells expressing the progesterone receptor (PR) using the MRI-contrast agent ProGlo. We find that nanodiamonds and ProGlo form a complex that targets nanodiamonds to cells expressing the PR while also markedly improving the water solubility and per-gadolinium relaxivity of ProGlo.