Sirna-Based Spherical Nucleic Acid Nanoparticle Conjugates Increase the Rate of Wound Healing in Subjects with Type 2 Diabetes

Randeria, Pratik ;   Paller, Amy S. ;   Mirkin, Chad

Diabetic patients often suffer from impaired wound healing, which can develop into non-healing diabetic ulcers, facilitate bacterial infections, and necessitate amputation. Current technologies, including artificial growth factors and dressings, have failed to achieve the anticipated efficacy, and incur the risk of side effects such as allergic reactions and immune rejection. In this work, we have developed a novel siRNA-nanoparticle conjugate based on the spherical nucleic acid platform. These conjugates have been shown to penetrate through skin, suppress a critical mediator of local insulin resistance via siRNA mediated RNA interference, and ultimately reverse the wound healing impairment in diabetic mice.