An Engineered Microfluidic Device for Modeling Cardiac Tissues

Acun, Aylin ;   Zorlutuna, Pinar

Studying the heart tissue is critical for understanding and developing treatments for cardiovascular diseases. In this work, we present a human induced pluripotent stem cell (hiPSC)-derived engineered cardiac tissue as an in vitro tissue model that has control over the tissue microenvironment through photocrosslinkable hydrogels and microfluidics. The designed three-channel microfluidic device allows spatial control over cultured hiPSC-derived cell types and has the ability to introduce interstitial flow and chemical gradients to cells within the device. The described system can be used as a physiologically relevant cardiac tissue model for applications ranging from disease modeling to personalized medicine.