Real Time Impedance Sensing of Intermediate Stages of Mitosis of a Single Cell
Kaji, Hirokazu ; Ghenim, Lamya ; Nagamine, Kuniaki ; Porte, Stephanie ; Haguet, Vincent ; Gidrol, Xavier ; Nishizawa, Matsuhiko
We have constructed a sensitive tool to monitor electrically changes of individual cells by combining electrochemical-based surface modification and positive dielectrophoresis with micrometric electrodes. Electrical cell-substrate impedance sensing coupled with optical observation has defined an electrical characterization for intermediate stages of mitosis for a single HeLa cell. Monitoring the impedance changes associated with the cell cycle might define differences between a single cancerous or healthy cell.