Effect of the Flexural Rigidity of a Piezoelectric Thin-Film on the Neonatal Rat Cardiomyocytes Maturation

Hsu, Yu-Hsiang ;   Lin, Yu-Huan ;   Chou, Han-Yi E. ;   Chen, Li-Yu ;   Shen, Jia-Wei

In this paper, a piezoelectric Polyvinylidene fluoride (PVDF) transducer for the mechanical detection of cardiomycytes is presented. In order to direct seeded neonatal rat cardiomyocyte to develop into a matured 2-D microtissue, the concept of flexible structure is introduced. We hypothesize that by controlling the flexural rigidity of the transducer, the relative higher stiffness of the PVDF polymer could be compensated. Preliminary study suggested that neonatal cardiomyocyte could develop into a myocyte-like morphology on the designed piezoelectric transducer with 8.82 Nμm2 fluxural rigidity.