Maximizing the Intracellular Delivery of Spherical Nucleic Acids by Engineering Oligonucleotide Sequence

Narayan, Suguna ;   Choi, Chung Hang J ;   Hao, Liangliang ;   Calabrese, Colin ;   Mirkin, Chad

Tags BionanotechnologyNanotechnologyNanomedicine

Spherical nucleic acids (SNAs), consisting of densely packed, highly oriented oligonucleotides attached to the surface of nanoparticles, are...

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Sirna-Based Spherical Nucleic Acid Nanoparticle Conjugates Increase the Rate of Wound Healing in Subjects with Type 2 Diabetes

Randeria, Pratik ;   Paller, Amy S. ;   Mirkin, Chad

Tags BionanotechnologyNanomedicineNanotechnology

Diabetic patients often suffer from impaired wound healing, which can develop into non-healing diabetic ulcers, facilitate bacterial infections,...

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Stickyflares: A Platform for the Quantification and Spatio-Temporal Tracking of RNA in Live Cells

Briley, William ;   Mirkin, Chad

Tags BionanotechnologyNanotechnologyNanomedicine

We report a novel gold nanoparticle-DNA conjugate, termed the Stickyflare, which provides a platform for facile quantification of relative RNA...

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