An Implantable 64-Channel Neural Interface with Reconfigurable Recording and Stimulation

Wheeler, Jesse ;   Baldwin, Keith ;   Kindle, Alex ;   Guyon, Daniel ;   Nugent, Brian ;   Segura, Carlos Alejandro ;   Rodriguez, John ;   Czarnecki, Andrew ;   DiSpirito, Hailey ;   Lachapelle, John ;   Moran, James ;   Parks, Philip ;   Widge, Alik ;   Dougherty, Darin ;   Eskandar, Emad

Tags Neural stimulation - Deep brainNeural interfaces - Implantable systemsNeural interfaces - Microsystems and microfabrication

Next generation implantable medical devices will have the potential to provide more precise and effective therapies through adaptive...

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Characterization of Fear Conditioning and Fear Extinction by Analysis of Electrodermal Activity

Faghih, Rose T. ;   Stokes, Patrick ;   Marin, Marie-France ;   Zsido, Rachel ;   Zorowitz, Sam ;   Rosenbaum, Blake ;   Song, Huijin ;   Milad, Mohammed ;   Dougherty, Darin ;   Eskandar, Emad ;   Widge, Alik ;   Brown, Emery N ;   Barbieri, Riccardo

Tags Brain physiology and modeling - Cognition, memory, perceptionNeurological disorders - Psychiatric disordersHuman performance - Cognition

Electrodermal activity (EDA) is a measure of physical arousal, which is frequently measured during psychophysical tasks relevant for anxiety...

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Cognitive State Prediction using an Expectation-Maximization Algorithm Applied to Gamma Distributed Data

Yousefi, Ali ;   Paulk, Angelique C ;   Deckersbach, Thilo ;   Dougherty, Darin ;   Eskandar, Emad ;   Widge, Alik ;   Eden, Uri

Tags Neural signals - FilteringNeural signals - Detection of transient eventsNeural signal processing

Behavioral tests are widely used to quantify features of cognitive processing. For a large class of behavioral signals, the observed variables...

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Estimating a Dynamic State to Relate Neural Spiking Activity to Behavioral Signals during Cognitive Tasks

Deng, Xinyi ;   Faghih, Rose T. ;   Barbieri, Riccardo ;   Paulk, Angelique C ;   Asaad, Wael F. ;   Brown, Emery N ;   Dougherty, Darin ;   Widge, Alik ;   Eskandar, Emad ;   Eden, Uri

Tags Brain physiology and modeling - Neural dynamics and computationHuman performance - CognitionRehabilitation - Cognition

An important question in neuroscience is understanding the relationship between high-dimensional electrophysiological data and complex, dynamic...

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Neural Signal Processing and Closed-Loop Control Algorithm Design for an Implanted Neural Recording and Stimulation System

Hamilton, Lei ;   McConley, Marc ;   Angermueller, Kai ;   Goldberg, David ;   Corba, Massimiliano ;   Kim, Louis ;   Parks, Philip ;   Chin, Sang ;   Widge, Alik ;   Dougherty, Darin ;   Eskandar, Emad ;   Moran, James

Tags Neural signal processingNeural stimulation - Deep brainNeural interfaces - Implantable systems

A fully autonomous intracranial device is built to continually record neural activities in different parts of the brain, process these sampled...

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Package Architecture and Component Design for an Implanted Neural Stimulator with Closed Loop Control

Parks, Philip ;   Bjune, Caroline ;   Marinis, Thomas ;   Sriram, Tirunelveli ;   Dougherty, Darin ;   Moran, James ;   Brady, Jeanne ;   Widge, Alik ;   Eskandar, Emad ;   Wheeler, Jesse

Tags Neural stimulation - Deep brainNeural interfaces - Implantable systemsNeural interfaces - Microsystems and microfabrication

An implanted neural stimulator with closed loop control requires electrodes for stimulation pulses and recording neuron activity. Our system...

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