A Dual Gate ISFET Array-Based System for Bioelectrochemical Detection of Mammalian Cells

Wen, Chin-Hua ;   Lin, Ching-Hui ;   Huang, J. C. ;   Hsieh, Kenny ;   Liu, Yi-Shao ;   Chen, Mark ;   Hsu, Chia-Hsien

Tags Bioelectric sensing methodsBiolelectric sensors and sensor systemsBiological sensors and systems

An arrayed biosensor comprising of 128 x 128 ion-sensitive field-effect-transistors with dual gate structure (DG-ISFETs) has been fabricated...

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A Microfluidic Platform for High-Throughput Drug Screening with 3D Cultured Cells

Chang, Hao-Chen ;   Lin, Ching-Hui ;   Juang, Duane ;   Lee, Che Yen ;   Chen, Chihchen ;   Hsu, Chia-Hsien

Tags Microfluidics in biological applicationsMicrofluidic techniques, methods and systems

The tumor is a three-dimensional architecture with cell-cell and cell-extracellular matrix interaction. These factors mediate the drug...

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A Novel Nanoporous Platinum Electrode for EEG Signal Quality Enhancement

Kim, Do Youn ;   Ku, Yunseo ;   Kwon, Chiheon ;   Ahn, Joong Woo ;   Kim, Hee Chan

Tags Bioelectric sensing methodsMicro- and nano-technologyPhysiological monitoring

An investigation of a novel nanoporous electrode is reported in this paper. Traditionally used in electrochemical applications, L2ePt (L2 phase...

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A Primary Study on Non-Contact Measurement of Vital Signs using the Microsoft Kinect Sensor

Ikarashi, Akira

Tags Physiological monitoring

The sleep apnea syndrome is diagnosed using polysomnography, which the patient is attached to multiple sensors. Accordingly, polysomnography...

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A Soft Contact-Lens with Integrated Microfluidic System for Controlled Collection of Basal Tear

Kim, Ockchul ;   Jeong, Jinwoo ;   Song, Yong-Won ;   Kim, Jinseok

Tags Microfluidic techniques, methods and systemsMicrofluidics in biological applicationsWearable systems

The current methods for collecting and extracting basal tear for non-invasive biochemical analysis causes dilution by the reflex tear due to...

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A System with Line Lasers and Webcam for 3D Reconstruction: A Feasibility Study

Barone, Vinicio ;   Verdini, Federica ;   Di Nardo, Francesco ;   Burattini, Laura ;   Fioretti, Sandro

Tags Optical and photonic sensors and systems

A prototype system has been designed to analyze the movement of a subject, using a single webcam and a series of line lasers of low cost...

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A Versatile CMOS Bio-Electronic Chip with Microfluidic Channels for Point-of-Care Cell Counting Applications

Huang, Yu-Jie ;   Lin, Ching-Hui ;   Huang, J. C. ;   Hsieh, Kenny ;   Liu, Yi-Shao ;   Chen, Mark ;   Hsu, Chia-Hsien

Tags Biolelectric sensors and sensor systemsBioelectric sensing methodsMicro- and nano-sensors

A versatile semiconductor bio-electronic chip with microfluidic channels is presented for point-of-care (POC) cell counting. The developed...

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An Instrument for Quantifying Optical and Mechanical Properties of Soft Tissue Membranes

Dixon, Alexander William ;   Jor, Jessica ;   Nash, Martyn ;   Nielsen, Poul ;   Taberner, Andrew

Tags Mechanical sensors and systemsOptical and photonic sensors and systems

A novel instrument has been developed for quantifying the optical and mechanical properties of membranes containing collagen. Tests with the...

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Angiogenesis Imaging in a Cell Culture Microfluidic Device Mimicking the Tumor Microenvironment

Kadokura, Kanae ;   Sato, Asako ;   Uchida, Hideyuki ;   Tsukada, Kosuke

Tags Microfluidics in biological applicationsMicrofluidic techniques, methods and systems

Angiogenesis, the formation of new blood vessels from existing ones, is a determinant of tumor growth and a target for cancer therapy....

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Capacitive Sensing for Non-Invasive Breathing and Heart Rate Monitoring in Non-Restrained, Non-Sedated Adult Mice

González-Sánchez, Carlos ;   Schmitt, Daniel ;   Damm, Ellen ;   Schneider, Jochen ;   Zimmermann, Heiko ;   Fraile, Juan Carlos ;   Ihmig, Frank

Tags Physiological monitoringBiolelectric sensors and sensor systemsBioelectric sensing methods

We describe the use of commercially available capacitive sensors for non-invasive physiological variables acquisition in non-restrained,...

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Centrifugal Microfluidic-Based Viscometer

Park, Jiheum ;   Lee, Jung Chan ;   Kim, Hee Chan

Tags Microfluidics in biological applicationsMicrofluidic techniques, methods and systems

Viscosity of the fluid is one of the key indicators in chemical and biological studies to represent fluidic conditions. However, commercially...

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Development of a Closed Bag Type Humidifying Container using a Newly Developed Nanofiber Sheet Membranes

Okazaki, Toshihiko

Tags Micro- and nano-technology

We newly developed the nano fiber sheet (NF) which exhibit superior functions of both moisture permeability and waterproofing performance....

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Development of a Fluidic Gripper for Isolated Cardiomyocytes

Yamaguchi, Yohei ;   Yamaguchi, Yasuyo ;   Wakimoto, Shuichi ;   Iribe, Gentaro ;   Naruse, Keiji

Tags Micro- and nano-technology

All cells in the heart are subject to dynamic change in stress and strain during the cycle of contraction and relaxation. Therefore,...

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Development of a Perfusion Bioreactor used for Stem Cells Large-Scale Cultivation

Hou, Qian ;   Gao, Yu-Bao ;   Huang, Shao-Xiong ;   Tang, Ying ;   Luo, Yu-Xi

Tags Biological sensors and systems

A new type of stem cell bioreactor proposed in this paper were made of multi-storey circular parallel plate bracket, which provides a high...

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Development of an Optical Monitoring System of Urine Substances for Home Healthcare

Tanaka, Shinobu ;   Suzuki, Ikuto ;   Nogawa, Masamichi ;   Naito, Hisashi ;   Ogawa, Mitsuhiro ;   Yamakoshi, Ken-ichi

Tags Optical and photonic sensors and systems

We have been developing an optical system for monitoring urinary substances. In this study, we carried out preliminary experiments for...

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Development of Customized Alertness and Fatigue Monitoring System for Workers under Critical Environment

Kim, Dongsoo ;   Lee, Wooil ;   Koo, Hyojin ;   Hwang, Sunyu

Tags Physiological monitoringIntegrated sensor systemsBiological sensors and systems

To ensure safety and enhance performance by controlling the workload amongst workers under critical environment, real-time alertness and...

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Distance Dependent Activation of Dissociated Hippocampal Network by Tetanic Stimulation

Tanaka, Yukimi ;   Isomura, Takuya ;   Shimba, Kenta ;   Kotani, Kiyoshi ;   Jimbo, Yasuhiko

Tags Microfluidics in biological applicationsMicrofluidic techniques, methods and systems

Several studies have reported hippocampal dentate gyrus has a central role in the pattern separation. However, little is known about the...

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Efficient Capture of Single Tumor Cells using a Bypass Integrated 3-Dimensional Microfluidic Trap Array

Lee, Jusin ;   Yoon, Yousang ;   Kim, Rae-Kwon ;   Lee, Su-Jae ;   Sul, Onejae ;   Lee, Seung-Beck

Tags Microfluidics in biological applicationsMicrofluidic techniques, methods and systems

We report on a size-based bypass integrated microfluidic trap array that has improved cell capture efficiency. By adjusting the height of...

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Electrochemical Biosensor based on MoS2-Graphene and IgG-HRP/ALP Nanocomposite

Kim, Hyeong-U ;   Kim, Hyeyoun ;   Ahn, Chisung ;   Kulkarni, Atul ;   Lee, Min-Ho ;   Taesung, Kim

Tags Biocompatibility of implantable sensorsChemo/bio-sensing techniquesChemical sensors and systems

A self-assembled novel nanocomposite composed of MoS2-graphene (MoS2-Gr) composite and HRP-IgG/ALP-IgG was electrostatically formed on gold...

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High-Efficiency Single-Cell Loading in Large Microwells using a Hydrodynamic Shuttling Chip

He, Cheng-Kun ;   Lin, Ching-Hui ;   Chang, Hao-Chen ;   Chen, Chihchen ;   Hsu, Chia-Hsien

Tags Microfluidic techniques, methods and systemsMicrofluidics in biological applications

we present a microfluidic device which utilizes hydrodynamic force to load single cells into microwells. The microfluidic device consists of an...

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Improving the Efficiency of ECG Monitor for m-Health Applications

Vasyltsov, Ihor ;   Lee, Seunghwan ;   Bak, Changgyu

Tags Physiological monitoringLow power, wireless sensing methodsWearable systems

In this paper a method for efficient ECG signals monitoring for m-Health applications has been presented. Our experiments showed that for...

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Influence of Interstitial Level of Shear Flow for Human Adipose-Derived Stem Cells (hASCs) in Microfluidic System

Ahn, Kihoon ;   Lee, Gi-Hun ;   Park, Joong Yull

Tags Microfluidics in biological applicationsMicrofluidic techniques, methods and systemsMicro- and nano-technology

Shear stress has a particular role for stem cell differentiation. In vivo stem cells are exposed to interstitial flow which is extremely slow...

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Label-Free Gold Nanoparticle-Based Colorimetric Assay for Direct Detection of Cryptosporidium using Smartphone

Luka, George Said ;   Urmi, Nusrat Jahan ;   Singh Bachhal, Jannat ;   Diaz de Leon Derby, Maria ;   Van den Berg, André Christiaan ;   Roberts, Deborah J. ;   Najjaran, Homayoun ;   Hoorfar, Mina

Tags Optical and photonic sensors and systemsPortable miniaturized systems

We introduce a label-free gold nanoparticle-based colorimetric assay for the direct detection of Cryptosporidium. An integrated...

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Label-Free Strategy for Single-Cell Detection of in Vitro Activated T Lymphocytes

Rollo, Enrica ;   Tenaglia, Enrico ;   De Micheli, Andrea Joseph ;   Guiducci, Carlotta ;   Harari, Alexandre ;   Genolet, Raphael

Tags Biological sensors and systemsMicrofluidics in biological applicationsMicro- and nano-sensors

In this work we present a label-free strategy for the single-cell detection of in vitro activated T lymphocytes, based on 3D free-standing...

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Loss Tangent as a Bioimpedance Parameter – Ischemic Small Intestine

Strand-Amundsen, Runar ;   Ruud, Tom Erik ;   Aasen, Ansgar O. ;   Kalvøy, Håvard ;   Tronstad, Christian ;   Høgetveit, Jan Olav

Tags Biolelectric sensors and sensor systemsPhysiological monitoring

We report that the loss tangent (dielectric parameter) is highly sensitive to time dependent changes in ischemic small intestine. We measured...

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Non-Invasive Sensors for Wound Monitoring and Therapy

Salvo, Pietro ;   Melai, Bernardo ;   Bianchi, Sabrina ;   Calisi, Nicola ;   Dini, Valentina ;   Romanelli, Marco ;   Castelvetro, Valter ;   Paoletti, Clara ;   Politino, Consuelo ;   Di Francesco, Fabio

Tags Physiological monitoringBiological sensors and systemsWearable systems

Chronic wounds such as diabetic foot ulcers and venous leg ulcers affect in Europe more than 10 million people, a number that is expected to...

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Optimization of Implanted Miniaturized Helix Antenna for Drug Delivery Control

Mermigkas, Panagiotis ;   Christopoulou, Maria ;   Nikita, Konstantina

Tags Implantable sensors

In this paper, we propose an optimized miniaturized helix antenna with different frequency response when its enclosed drug container is full...

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Post-Fabrication Detection of Failure Modes in Parylene-Based Neural Probes

Scopelliti, Matteo Giuseppe ;   Mukund, Vidush ;   Dedola, Francesca ;   Chamanzar, Maysamreza ;   Maharbiz, Michel ;   Blanche, Tim

Tags Implantable technologiesMicro- and nano-sensorsBiolelectric sensors and sensor systems

Here we discuss an efficient method to detect failure modes of neural probes made of multi-layer parylene C and metal interconnects that...

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Supercapacitors and Li-Batteries as Rechargeable Energy Storage for Implantable Biomedical Devices: A Critical Comparison

Barboza, Juliano ;   Aqueveque, Pablo ;   Saavedra, Francisco

Tags Implantable technologiesWireless sensors and systemsLow power, wireless sensing methods

Most active implants that have a rechargeable power source use a secondary Li-Battery. The Supercapacitor (SC) can be a suitable...

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Targeted Delivery of OncomiR-Inhibiting Peptide Nucleic Acids to Melanoma by pHLIP

Svoronos, Alexander ;   Bahal, Raman ;   Barrera, Francisco ;   Meeth, Katrina ;   Cheng, Christopher ;   Glazer, Peter ;   Bosenberg, Marcus ;   Engelman, Donald

Tags Bio-nano technologyMicro- and nano-technology

MicroRNAs are short, 18-25 nucleotide-long RNA molecules that are heavily dysregulated in nearly all cancers. By inhibiting oncogenic or tumor...

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Texture Sensor with Bio-Mimetic Fingerprint Ridge Structure

Kim, Hongjun ;   Choi, Eunsuk ;   Kim, JuYoung ;   Kim, Kyu Min ;   Sul, Onejae ;   Lee, Seung-Beck

Tags Bioelectric sensing methodsBiolelectric sensors and sensor systemsBiological sensors and systems

We report on a texture sensor incorporating a bio-mimetic fingerprint ridge structure. Our ridge structure which mimics the structure of...

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Transmission of Information among Cell Assemblies in Engineered Living Hippocampal Networks

DeMarse, Thomas B. ;   Bhattacharya, Aparajita ;   Brewer, Gregory ;   Wheeler, Bruce

Tags Micro- and nano-technologyPhysiological monitoringBioelectric sensing methods

Transiently active neuronal cell assemblies are thought to underlie many properties of the brain and form the basis for complex cognitive...

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Two-Dimensional Microbubble Collection in an Acoustic Vortex

Lo, Wei-Chen ;   Kang, Shih-Tsung ;   Yeh, Chih-Kuang

Tags Acoustic sensors and systemsMicro- and nano-technology

The hollow beam axis of an acoustic vortex has been shown to produce a two-dimensional acoustic potential well for microbubbles (MBs) in a...

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Volatility of Pronation and Supination in Children with ADHD

Kaneko, Miki ;   Iramina, Keiji

Tags Wireless sensors and systemsWearable systemsBody sensor networks and telemetric systems

Pronation and supination is one of evaluation methods in soft neurological signs (SNS). SNS are used as criteria of developmental brain...

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Voxel-Based Pose-Deformable Models with Human Anatomy by Kinect for Electromagnetic Simulation

Nagaoka, Tomoaki ;   Watanabe, Soichi

Tags Wireless sensors and systemsBody sensor networks and telemetric systemsImplantable sensors

We previously developed a pose deformation method for computational models with human anatomy applied to the free-form deformation...

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Wireless Multi-Parameter Ear-Lead Smart Sensor System with Fingerprint Identity Management in M-Health

Celik, Numan ;   Balachandran, Wamadeva ;   Manivannan, Nadarajah

Tags Integrated sensor systemsBody sensor networks and telemetric systemsPhysiological monitoring

This project presents a multi-parameter smart sensor system within a smartphone to enable a continuous unobtrusive monitoring of core body...

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