A Compound Ampoule for Large-Volume Controllable Jet Injection

Ruddy, Bryan ;   Mckeage, James William ;   Williams, Rhys Matthew James ;   Nielsen, Poul ;   Taberner, Andrew

Tags Transdermal drug deliveryDesign and development

We present a new design for a needle-free injector ampoule, using two concentric pistons to pressurize the fluid during the injection. The...

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Adaptive Controller for a Needle Free Jet-Injector System

Modak, Ashin ;   Hogan, N. Catherine ;   Hunter, Ian

Tags Transdermal drug deliveryDesign and developmentInnovation

A nonlinear, sliding mode adaptive controller was created for a needle-free jet injection system. The controller was based on a simplified...

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Human Feasibility Study of Fluorescence Spectroscopy Guided Optical Biopsy Needle for Prostate Cancer Diagnosis

Werahera, Priya N. ;   Jasion, Edward ;   Liu, Yongjun ;   Daily, John W. ;   Arangua, Paul ;   Jones, Cliffod ;   Nash, S. Russell ;   Morrell, Michael ;   Crawford, E. David

Tags Clinical trialsDesign and developmentInnovation

Current prostate biopsy cores have a very low diagnostic yield. These biopsies often fail to diagnose prostate cancer since 90% of cores are...

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Jet Injection of a Monoclonal Antibody: A Preliminary Study

Hogan, N. Catherine ;   Cloutier, Alison ;   Hunter, Ian

Tags Transdermal drug delivery

Monoclonal antibodies (mAbs) represent a major group of biotherapeutics. The high concentration and volume of drug administered together...

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Optimization of Drug Viscosity used in Gas-Powered Liquid Jet Injectors

Portaro, Rocco ;   Nakayama, Haruka ;   Ng, Hoi Dick

Tags Transdermal drug deliveryClinical engineering

This paper describes the effect of drug viscosity on the performance of gas powered liquid jet injectors. The analysis is accomplished...

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The Effect of Jet Shape on Jet Injection

Park, Geehoon ;   Modak, Ashin ;   Hogan, N. Catherine ;   Hunter, Ian

Tags Transdermal drug delivery

The effects of the dispersion pattern of a needle-free jet injector are explored. The shape of the jets were compared using a high-speed...

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