A Computational Model of Dopamine and Acetylcholine Aberrant Learning in Basal Ganglia

Baston, Chiara ;   Ursino, Mauro

Tags Network modelingAlgorithms and techniques for systems modeling

Basal Ganglia (BG) are implied in many motor and cognitive tasks, such as action selection, and have a central role in many pathologies,...

Read More Download this Paper

A Network-Based Approach to Enrich Gene Signatures for the Prediction of Breast Cancer Metastases

Sfakianakis, Stelios ;   Bei, Ekaterini ;   Zervakis, Michalis ;   Kafetzopoulos, Dimitris

Tags Analysis of high-throughput systems biology dataBiomedical data-driven modelingNetwork modeling

Despite the multiplicity of the gene expression analysis studies for the identification of genomics based origins of cancerous diseases, the...

Read More Download this Paper

An Approach for Optimally Extending Mathematical Models of Signaling Networks using Omics Data

Bianconi, Fortunato ;   Patiti, Federico ;   Baldelli, Elisa ;   Crinò, Lucio ;   Valigi, Paolo

Tags Algorithms and techniques for systems modelingModeling of biomolecular system dynamicsNetwork modeling

Mathematical modeling is a key process in Systems Biology and the use of computational tools such as Cytoscape for <i>omics</i> data...

Read More Download this Paper

Differentiating Disease Subtypes by using Pathway Patterns Constructed from Gene Expressions and Protein Networks

Hung, Fei-Hung ;   Chiu, Hung-Wen

Tags Biomedical data-driven modelingAnalysis of high-throughput systems biology dataAlgorithms and computational tools for proteomics

Gene expression profiles differ in different diseases. Even if diseases are at the same stage, such diseases exhibit different gene...

Read More Download this Paper

Identifying Gene Subnetworks Associated with Clinical Outcome in Ovarian Cancer using Network based Coalition Game

Razi, Abolfazl ;   Afghah, Fatemeh ;   Varadan, Vinay

Tags Analysis of high-throughput systems biology dataAlgorithms and techniques for systems modelingNetwork modeling

The problem of identifying interacting genes that jointly are associated with a phenotype is considered. When the number of features are...

Read More Download this Paper

Modeling HPV Early Promoter Regulation

Giaretta, Alberto ;   Di Camillo, Barbara ;   Barzon, Luisa ;   Toffolo, Gianna

Tags Modeling of gene/epigene regulatory networksNetwork modeling

In high risk forms, human papillomaviruses (HPV) can either induce or promote cancerous lesions, especially cervical cancer which is considered...

Read More Download this Paper

Non-Linear Bayesian Framework to Determine the Transcriptional Effects of Cancer-Associated Genomic Aberrations

Razi, Abolfazl ;   Banerjee, Nilanjana ;   Dimitrova, Nevenka ;   Varadan, Vinay

Tags Analysis of high-throughput systems biology dataModeling of gene/epigene regulatory networksAlgorithms and techniques for systems modeling

While the tumorigenic effects of specific recurrent mutations in known cancer driver-genes is well-characterized, not much is known about the...

Read More Download this Paper