A Control-Theoretical Approach to the Identification of a Commitment Switch in B Lymphopoiesis Cell Fate Determination

Salerno, Luca ;   Cosentino, Carlo ;   Morrone, Giovanni ;   Bilotta, Mariaconcetta ;   Amato, Francesco

Tags Modeling of gene/epigene regulatory networksStem cellsAdvances in theory of biological networks

Cellular differentiation is continuously orchestrated by complex networks of transcription factors, signaling molecules and genetic and...

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A Mathematical Model of the Calcium Transient in Urinary Bladder Smooth Muscle Cells

Dave, Vijay ;   Mahapatra, Chitaranjan ;   Manchanda, Rohit

Tags Modeling of biomolecular system dynamicsPhysiological systemsCell modeling

An increase in cytoplasmic calcium (Ca2+) concentration ([Ca2+]i) is a prerequisite for the contraction of detrusor smooth muscle (DSM) cells...

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Computational Studies on Bladder Small Dorsal Root Ganglion Neurons: Modelling BK Channels

Mandge, Darshan ;   Manchanda, Rohit

Tags Cell modelingIonic modelingPhysiological systems

The urinary bladder afferent neurons called the dorsal root ganglion (DRG) neurons carry information on diverse modalities such as stretch,...

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Dynamics of Cancer Progression and Suppression: A Novel Evolutionary Game Theory based Approach

Banerjee, Jeet ;   Ranjan, Tanvi ;   Layek, Ritwik

Tags Physiological systems

In this manuscript, a novel mathematical approach is proposed for the dynamics of progression and suppression of cancer. We define mutant...

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Epithelial Mesenchymal Transition in Lung Cancer Cells: A Quantitative Analysis

Sarkar, Atasi ;   Barui, Ananya ;   Sengupta, Sanghamitra ;   Chatterjee, Jyotirmoy ;   Ghorai, Santanu ;   Mukherjee, Anirban

Tags Medical decision making

Cellular auto-fluorescence along with morphological and cytoskeletal features were assessed in lung cancer cells undergoing induced epithelial...

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Impairment of Energy Metabolism in Cardiomyocytes Caused by 5-FU Catabolites can be Compensated by Administration of Amino Acids

Lischke, Julia ;   Lang, Christine ;   Sawodny, Oliver ;   Feuer, Ronny

Tags Clinical applications of biological networksModeling of biomolecular system pathwaysBiomedical data-driven modeling

Identification of patients with increased risk of 5-fluorouracil (5-FU)-related toxicity is an important challenge for cancer treatment....

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