Electrostatic Study of Alanine Mutational Effects on Transcription: Application to GATA-3: DNA Interaction Complex

El-Assaad, Atlal ;   Dawy, Zaher ;   Nemer, Georges

Tags Modeling of biomolecular system dynamicsAlgorithms and computational tools for proteomicsAlgorithms and techniques for systems modeling

Protein-DNA interaction is of fundamental importance in molecular biology, playing roles in functions as diverse as DNA transcription, DNA...

Read More Download this Paper

Evaluation of a Plasma Insulin Model for Glycaemic Control in Intensive Care

Dickson, Jennifer ;   Thomas, Felicity ;   Pretty, Christopher G. ;   Stewart, Kent ;   Shaw, Geoffrey M ;   Chase, J. Geoffrey

Tags Modeling of biomolecular system dynamicsBiomedical data-driven modelingMedical decision making

Hyperglycaemia is a common complication in the intensive care unit (ICU), and is associated with worsened outcomes. Model-based insulin therapy...

Read More Download this Paper

Identifying MIRNA-Mediated Signaling Subpathways by Integrating Paired MIRNA/MRNA Expression Data with Pathway Topology

Vrahatis, Aristidis ;   Dimitrakopoulos, Georgios ;   Tsakalidis, Athanasios ;   Bezerianos, Anastasios

Tags Modeling of biomolecular system dynamicsAlgorithms and techniques for systems modelingModeling of biomolecular system pathways

In the road for network medicine the newly emerged systems-level subpathway-based analysis methods offer new disease genes, drug targets...

Read More Download this Paper

Modeling the LPS-induced Effects on Transcription Factor Activation and Gene Expression in Murine Macrophages

Sanwald, Julia ;   Albrecht, Ute ;   Wagenpfeil, Jay ;   Thomas, Maria ;   Sawodny, Oliver ;   Bode, Johannes G. ;   Feuer, Ronny

Tags Modeling of biomolecular system dynamicsModeling of biomolecular system pathways

Macrophages within the liver are of particular importance for a functional defense against bacterial infection. They exhibit a complex...

Read More Download this Paper

MRI-Guided Epilepsy Detection

Zamani Pedram, Maysam ;   Shamloo, Amir ;   Alasty, Aria ;   Ghafar-Zadeh, Ebrahim

Tags Modeling of biomolecular system dynamicsInverse problems in biologyPhysiological systems

one of the most common neurological brain disorder is epilepsy that happen as an abrupt seizure. Around 30% of patients with epilepsy resist...

Read More Download this Paper

Selection and Mutation in X-Linked Recessive Diseases Epidemiological Model

Verrilli, Francesca ;   Kebriaei, Hamed ;   Glielmo, Luigi ;   Corless, Martin J. ;   Del Vecchio, Carmen

Tags Modeling of biomolecular system dynamicsMedical decision makingAlgorithms and techniques for systems modeling

To describe the epidemiology of X-linked recessive diseases we developed a discrete time, structured, non linear mathematical model. The model...

Read More Download this Paper