A Semi-Mechanistic Pharmacokinetic Model of Saquinavir Combined with Itraconazole in HIV-1-Positive Patients

Lohitnavy, Manupat ;   Methaneethorn, Janthima ;   Sriarwut, Thanyalak ;   Pankaew, Anongnat ;   Jenjob, Anchalee ;   Phuphuk, Kiatiphong

Tags PK/PD

The mechanism of drug-drug interaction between saquinavir, a protease inhibitor used effectively for HIV/AIDS treatment, and itraconazole, an...

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An Evaluation of the Emergence of Drug Resistant Virus for HIV/AIDS Drug Treatments

Chang, H.J.

Tags Advances in theory of biological networksMedical decision makingAlgorithms and techniques for systems modeling

HIV/AIDS drug treatment, such as highly active anti-retroviral therapy (HAART), often fails due to the emergence of drug resistant species....

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Differential Pathlength Factor Estimation for Brain-Like Tissue from a Single-Layer Monte Carlo Model

Chatterjee, Subhasri ;   Phillips, Justin ;   Kyriacou, Panayiotis

Tags Algorithms and techniques for systems modelingParameter estimation

A Monte Carlo simulation-based computational model has been developed for tracing the pathway of light within a single layer of tissue like...

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GPU Technology as a Platform for Accelerating Physiological Systems Modeling based on Laguerre-Volterra Networks

Papadopoulos, Agathoklis ;   Kostoglou, Kyriaki ;   Mitsis, Georgios D. ;   Theocharides, Theocharis

Tags Biomedical data-driven modelingPhysiological systems

The use of a GPGPU programming paradigm (running CUDA-enabled algorithms on GPU cards) in biomedical engineering and biology-related...

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Identification of Dynamical Biological Systems based on Random Effects Models

Batista, Levy ;   Bastogne, Thierry ;   Djermoune, El Hadi

Tags Algorithms and techniques for systems modelingParameter estimationBiomedical data-driven modeling

System identification is a data-driven modeling approach more and more used in biology and biomedicine. In this application context, each assay...

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Incorporation of Inhaled Insulin into the FDA Accepted University of Virginia/Padova Type 1 Diabetes Simulator

Visentin, Roberto ;   Klabunde, Thomas ;   Grant, Marshall ;   Dalla Man, Chiara ;   Cobelli, Claudio

Tags Physiological systemsPK/PDParameter estimation

The University of Virginia/Padova Type 1 Diabetes (T1DM) Simulator has been extensively used in artificial pancreas research mostly for testing...

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Inference of Asynchronous Boolean Network from Biological Pathways

Das, Haimabati ;   Layek, Ritwik

Tags Algorithms and techniques for systems modelingAdvances in theory of biological networksModeling of biomolecular system dynamics

Gene regulation is a complex process with multiple levels of interactions. In order to describe this complex dynamical system with tractable...

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Mathematical Modeling of Tumor Response to Radiation: Radio-Sensitivity Correlation with BOLD, TOLD, ?R1 and ?R2* Investigated in Large Dunning R3327-AT1 Rat Prostate Tumors

Belfatto, Antonella ;   White, Derek A. ;   Zhang, Zhongwei ;   Zhang, Zhang ;   Cerveri, Pietro ;   Baroni, Guido ;   Mason, Ralph P.

Tags Parameter estimationAlgorithms and techniques for systems modelingBiomedical data-driven modeling

Tumor response to radiation therapy can vary highly across patients. Several factors, both tumor- and environment-specific, can influence...

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New VHP-Female V. 2.0 Full-Body Computational Phantom and Its Performance Metrics using FEM Simulator ANSYS HFSS

Yanamadala, Janakinadh ;   Noetscher, Gregory ;   Rathi, Vishal ;   Maliye, Saili ;   Win, Htay Aung ;   Tran, Anh Le ;   Jackson, Xavier Jamel ;   Htet, Aung Thu ;   Kozlov, Mikhail ;   Nazarian, Ara ;   Louie, Sara ;   Makarov, Sergey

Tags Medical device modelingAlgorithms and techniques for systems modelingMedical decision making

Simulation of the electromagnetic response of the human body relies heavily upon efficient computational models or phantoms. The first...

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Online Prediction of Glucose Concentration in Type 1 Diabetes using Extreme Learning Machines

Georga, Eleni I. ;   Protopappas, Vasilios C. ;   Polyzos, Demosthenes ;   Fotiadis, Dimitrios I.

Tags Biomedical data-driven modelingAlgorithms and techniques for systems modelingPhysiological systems

We propose an online machine-learning solution to the problem of nonlinear glucose time series prediction in type 1 diabetes. Recently, extreme...

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Pharmacokinetic Model for the Inhibition of Simvastatin Metabolism by Itraconazole

Lohitnavy, Manupat ;   Methaneethorn, Janthima ;   Chian-Ngernthanyakool, Rangsimaporn ;   Tongpeng, Wasinee ;   Chan-IM, Daranee ;   Phaohorm, Suttipong

Tags PK/PD

Background: Concomitant use of simvastatin, a HMG-CoA reductase inhibitor, with a potent CYP3A4 inhibitor, itraconazole, can result in a...

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Predicting Protein Function from Biomedical Text

Taha, Kamal ;   Yoo, Paul

Tags Algorithms and techniques for systems modelingAlgorithms and computational tools for proteomicsBiomedical data-driven modeling

We propose a classifier system called PFPBT that predicts the functions of un-annotated proteins. PFPBT assigns an un-annotated protein p...

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Software Tools for Data Modelling and Processing of Human Body Temperature Circadian Dynamics

Petrova, Elena ;   Afanasova, Anastasiya

Tags Algorithms and techniques for systems modelingParameter estimationMedical device modeling

This paper is presenting a software development for simulating and processing thermometry data. The motivation of this research is the...

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Study of 1-year-old Baby Exposure to 3G Tablet Device using Polynomial Chaos

Liorni, Ilaria ;   Parazzini, Marta ;   Fiocchi, Serena ;   Kersaudy, Pierric ;   Varsier, Nadege ;   Ravazzani, Paolo ;   Wiart, Joe

Tags Algorithms and techniques for systems modelingMedical device modelingParameter estimation

Nowadays there is still concern about the exposure to Radio-Frequency electromagnetic fields (RF-EMF) due to the spread of new RF devices...

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The Volterra Functional Series is a Viable Alternative to Kinetic Models for Synaptic Modeling – Calibration and Benchmarking

Hu, Eric ;   Bouteiller, Jean-Marie Charles ;   Song, Dong ;   Berger, Theodore

Tags Multiscale modelingModeling of biomolecular system dynamicsAlgorithms and techniques for systems modeling

Synaptic transmission is governed by a series of complex and highly nonlinear mechanisms and pathways in whichthe dynamics have a profound...

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Uncovering Microbial Duality within Human Microbiomes: A Novel Algorithm for the Analysis of Host-Pathogen Interactions

Coelho, Edgar Duarte ;   Arrais, Joel Perdiz ;   Oliveira, José Luis

Tags Physiological systemsModeling of biomolecular system pathwaysAlgorithms and techniques for systems modeling

Microbial species thrive within human hosts by establishing complex associations between themselves and the host. Even though species...

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