A 3-D Admittance-Level Computational Model of a Rat Hippocampus for Improving Prosthetic Design

Gilbert, Andrew ;   Loizos, Kyle ;   RamRakhyani, Anil ;   Hendrickson, Phillip ;   Lazzi, Gianluca ;   Berger, Theodore

Tags Multiscale modelingMedical device modeling

Hippocampal prosthetic devices have been developed to bridge the gap between functioning portions of the hippocampus, in order to restore...

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A Million-Plus Neuron Model of the Hippocampal Dentate Gyrus: Dependency of Spatio-Temporal Network Dynamics on Topography

Hendrickson, Phillip ;   Yu, Gene ;   Song, Dong ;   Berger, Theodore

Tags Brain physiology and modeling - Neuron modeling and simulation

This paper describes a million-plus granule cell compartmental model of the rat hippocampal dentate gyrus, including excitatory, perforant path...

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Design of a Flexible Parylene-Based Multi-Electrode Array for Multi-Region Recording from the Rat Hippocampus

Xu, Huijing ;   Hsiao, Min-Chi ;   Meng, Ellis ;   Berger, Theodore ;   Song, Dong

Tags Neural interfaces - Microelectrode technologyNeural interfaces - Implantable systemsBrain physiology and modeling - Cognition, memory, perception

The hippocampus is a critical deep brain structure in several aspects. It is directly related to the formation of new long-term declarative...

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Estimation of a Large-Scale Generalized Volterra Model for Neural Ensembles with Group Lasso and Local Coordinate Descent

Robinson, Brian ;   Song, Dong ;   Berger, Theodore

Tags Brain physiology and modeling - Neural dynamics and computationNeural signals - Nonlinear analysisBrain physiology and modeling - Neuron modeling and simulation

Estimation of neural models based on observed spike timing faces challenges as the amount of recorded units increases, especially when...

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Sparse Generalized Volterra Model of Human Hippocampal Spike Train Transformation for Memory Prostheses

Song, Dong ;   Robinson, Brian ;   Hampson, Robert ;   Marmarelis, Vasilis ;   Deadwyler, Sam ;   Berger, Theodore

Tags Brain physiology and modeling - Neural dynamics and computationBrain physiology and modeling - Cognition, memory, perceptionNeural signals - Nonlinear analysis

In order to build hippocampal prostheses for restoring memory functions, we build multi-input, multi-output (MIMO) nonlinear dynamical models of...

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The Volterra Functional Series is a Viable Alternative to Kinetic Models for Synaptic Modeling – Calibration and Benchmarking

Hu, Eric ;   Bouteiller, Jean-Marie Charles ;   Song, Dong ;   Berger, Theodore

Tags Multiscale modelingModeling of biomolecular system dynamicsAlgorithms and techniques for systems modeling

Synaptic transmission is governed by a series of complex and highly nonlinear mechanisms and pathways in whichthe dynamics have a profound...

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Topography-Dependent Spatio-Temporal Correlations in the Entorhinal-Dentate-CA3 Circuit in a Large-Scale Computational Model of the Rat Hippocampus

Yu, Gene ;   Hendrickson, Phillip ;   Song, Dong ;   Berger, Theodore

Tags Brain physiology and modeling - Neuron modeling and simulation

The correlation due to different topographies was characterized in a large-scale, biologically-realistic, computational model of the rat...

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