Dynamic Steering of in Vitro Cortical Neurons Using Field Stimulation

Hamilton, Franz ;   Akhavian, Alireza ;   Knaack, Gretchen ;   Charkhkar, Hamid ;   Minnikanti, Saugandhika ;   Kim, Woo-Ju ;   Kastee, Jemika ;   Peixoto, Nathalia

Tags Brain physiology and modeling - Neural dynamics and computation

Neurological disorders are often characterized by abnormal neuronal activity. In the case of epilepsy, this can manifest itself in the form of...

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Generalized Volterra Kernel Model Identification of Spike-Timing-Dependent Plasticity from Simulated Spiking Activity

Robinson, Brian ;   Song, Dong ;   Berger, Theodore

Tags Brain physiology and modeling - Neural dynamics and computationBrain physiology and modeling - Neuron modeling and simulationNeural signals - Nonlinear analysis

This paper presents a methodology to estimate a learning rule that governs activity-dependent plasticity from behaviorally recorded spiking...

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Generalizing Performance Limitations of Relay Neurons: Application to Parkinson's Disease

Agarwal, Rahul ;   Santaniello, Sabato ;   Sarma, Sridevi V.

Tags Brain physiology and modeling - Neuron modeling and simulationBrain physiology and modeling - Neural circuitsDeep brain stimulation - Closed-loop control

Relay cells are prevalent throughout sensory systems and receive two types of inputs: <i> driving and modulating</i>. The driving input...

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Implementation of the Excitatory Entorhinal-Dentate-CA3 Topography in a Large-Scale Computational Model of the Rat Hippocampus

Yu, Gene ;   Song, Dong ;   Berger, Theodore

Tags Brain physiology and modeling - Neural circuits

The topography, or the anatomical connectivity, of the excitatory entorhinal-dentate-CA3 circuit of the rat hippocampus has been implemented...

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Instability Detector of a Fragile Neural Network: Application to Seizure Detection in Epilepsy

Ehrens, Daniel ;   Sritharan, Duluxan ;   Sarma, Sridevi V.

Tags Brain physiology and modeling - Neural dynamics and computationNeurological disorders - Epilepsy

It has recently been proposed that the epileptic cortex is fragile in the sense that seizures manifest through small perturbations in the...

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Maximizing Relaxation Time in Oscillator Networks with Implications for Neurostimulation

Kumar, Gautam ;   Ching, ShiNung

Tags Brain physiology and modeling - Neural dynamics and computationDeep brain stimulationNeurological disorders - Treatment methodologies

High frequency deep brain stimulation (HF-DBS)is a pervasive clinical neurostimulation paradigm in which rapid(> 100Hz) pulses of electrical...

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