A Testbed to Explore the Optimal Electrical Stimulation Parameters for Suppressing Inter-Ictal Spikes in Human Hippocampal Slices

Hsiao, Min-Chi ;   Yu, Pen-Ning ;   Song, Dong ;   Liu, Charles Y. ;   Heck, Christi N. ;   Millett, David ;   Berger, Theodore

Tags Neurological disorders - EpilepsyNeurological disorders - Treatment methodologies

New interventions using neuromodulatory devices such as vagus nerve stimulation, deep brain stimulation and responsive neurostimulation are...

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Computing Network-Based Features from Intracranial EEG Time Series Data: Application to Seizure Focus Localization

Hao, Stephanie ;   Subramanian, Sandya ;   Jordan, Austin ;   Yaffe, Robert ;   Santaniello, Sabato ;   Jouny, Christophe ;   Bergey, Gregory ;   Anderson, William S. ;   Sarma, Sridevi V.

Tags Neurological Disorders, Epilepsy Brain functional imaging - EEG

The surgical resection of the epileptogenic zone (EZ) is the only effective treatment for many drug-resistant epilepsy (DRE) patients, but...

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Constraints Imposed by the Lower Extremity Extensor Synergy in Chronic Hemiparetic Stroke: Preliminary Findings

Sanchez, Natalia ;   Dewald, Julius P. A.

Tags Neurological disorders - StrokeMotor learning, neural control, and neuromuscular systemsHuman performance - Engineering

In the present manuscript we implemented the MultiLEIT, a lower extremity isometric torque measurement device to quantify spontaneous joint...

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Data Sample Size Needed for Prediction of Movement Distributions

Wright, Zachary ;   Fisher, Moria ;   Huang, Felix ;   Patton, James (Jim)

Tags Neurological disorders - StrokeNeurological disorders - Diagnostic and evaluation techniquesMotor learning, neural control, and neuromuscular systems

Human movement ability should be described not only by its typical behavior, but also by the wide variation in capabilities. This would mean that...

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Early Detection of Human Focal Seizures Based on Cortical Multiunit Activity

Park, Yun Sang ;   Hochberg, Leigh ;   Eskandar, Emad ;   Cash, Sydney ;   Truccolo, Wilson

Tags Neurological disorders - EpilepsyClinical neurophysiologyNeural signal processing

Approximately 50 million people in the world suffer from epileptic seizures. Reliable early seizure detection could bring significantly beneficial...

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Increased Shoulder Abduction Loads Decreases Volitional Finger Extension in Individuals with Chronic Stroke: Preliminary Findings

Lan, Yiyun ;   Yao, Jun ;   Dewald, Julius P. A.

Tags Neurological disorders - StrokeHuman performance - Activities of daily livingHuman performance

The ability to open the paretic hand is greatly affected after a stroke. The loss of finger extension has been previously reported during...

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Pilot Study on Quantitative Assessment of Muscle Imbalance: Differences of Muscle Synergies, Equilibrium-Point Trajectories, and Endpoint Stiffness in Normal and Pathological Upper-Limb Movements

Oku, Takanori ;   Uno, Kanna ;   Nishi, Tomoki ;   Kageyama, Masayuki ;   Phatiwuttipat, Pipatthana ;   Koba, Keitaro ;   Yamashita, Yuto ;   Murakami, Kenta ;   uemura, Mitsunori ;   Hirai, Hiroaki ;   Miyazaki, Fumio ;   Naritomi, Hiroaki

Tags Neurological disorders - Diagnostic and evaluation techniquesNeuromuscular systems - EMG processing and applications

This paper proposes a novel method for assessment of muscle imbalance based on muscle synergy hypothesis and equilibrium point (EP)...

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Sensorimotor Cortex Reorganization in Subacute and Chronic Stroke: A Neuronavigated TMS Study

Yarossi, Mathew ;   Adamovich, Sergei ;   Tunik, Eugene

Tags Clinical neurophysiology - Transcranial magnetic stimulationNeurological disorders - StrokeBrain functional imaging - Evoked potentials

The integrity of the corticospinal system is an important biomarker for recovery from stroke. However, mapping the topography of the...

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Unstable Periodic Orbits in Human Epileptic Hippocampal Slices

Yu, Pen-Ning ;   Hsiao, Min-Chi ;   Song, Dong ;   Liu, Charles Y. ;   Heck, Christi N. ;   Millett, David ;   Berger, Theodore

Tags Neurological disorders - EpilepsyBrain physiology and modelingNeural signals - Nonlinear analysis

Inter-ictal activity is studied in hippocampal slices resected from patients with epilepsy using local field potential recording. Inter-ictal...

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