A Pharmacokinetic Drug-Drug Interaction Model of Simvastatin and Clarithromycin in Humans

Methaneethorn, Janthima ;   Chaiwong, Krissanapong ;   Pongpanich, Komwut ;   Sonsingh, Phakawat ;   Lohitnavy, Manupat

Tags PK/PD

Background: Simvastatin is a HMG-CoA reductase Inhibitor and a substrate of CYP3A4. Clarithromycin is a commonly used macrolide antibiotics...

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A Pharmacokinetic Drug-Drug Interaction Model of Simvastatin and Verapamil in Humans

Methaneethorn, Janthima ;   Chamnansua, Munlikar ;   Kaewdang, Natnaree ;   Lohitnavy, Manupat

Tags PK/PD

Background: Verapamil is a calcium channel blocker commonly used in treatments of hypertension. Verapamil and its active metabolite,...

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A Pharmacokinetic Model of Lopinavir in Combination with Ritonavir in Human

Duangchaemkarn, Khanita ;   Lohitnavy, Manupat ;   Reisfeld, Brad

Tags PK/PDAlgorithms and techniques for systems modelingClinical applications of biological networks

Ritonavir-boosted lopinavir (LPV/r) has been recommended as an alternative regimen for HIV-naive patients who cannot tolerate nevirapine...

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Antibody-Based Molecular Communication for Targeted Drug Delivery Systems

Chahibi, Youssef ;   Akyildiz, Ian F. ;   Song, Sang Ok

Tags PK/PDNetwork modelingBiomedical data-driven modeling

Antibody-based drug delivery systems (ADDS) are established as the most promising therapeutic methods for the treatment of human cancers...

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Heart Rate Variability As an Indicator for Morphine Pharmacokinetics and Pharmacodynamics in Critically Ill Newborn Infants

Bressan, Nadja ;   McGregor, Carolyn ;   Smith, Kathleen P. ;   Lecce, Loreto ;   James, Andrew

Tags PK/PDMedical decision makingBiomedical data-driven modeling

Morphine is the commonest drug used for analgesia in newborn infants. It is a natural opioid that acts as an agonist at the mu and kappa...

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Pharmacokinetic Modeling of Simvastatin, Nelfinavir and Their Interaction in Humans

Methaneethorn, Janthima ;   Patcharaporn, Kunyamee ;   Jindasri, Warangkana ;   Wattanasaovaluk, Warunee ;   Kraiboot, Anoot ;   Lohitnavy, Manupat

Tags PK/PD

Background: Simvastatin, a commonly used HMG-CoA reductase inhibitor, is extensively metabolized by CYP3A4. Therefore, co-administration of...

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