A Mock Circulatory Loop for Designing and Evaluating Total Artificial Hearts

Love, Holley ;   Timms, Daniel Lee ;   Nestler, Frank ;   Frazier, O.H. ;   Cohn, William E.

Tags Cardiovascular system modelingArtificial heart and valvesCirculation models

A mock circulatory loop was constructed to facilitate total artificial heart development. The loop includes many novel features such as a...

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Inducing Valvular Regurgitation in Mice Via Thermal Ablation of Cardiac Valves

Mulchrone, Ashley ;   Brace, Christopher ;   Hacker, Timothy ;   Chesler, Naomi

Tags Heart failureCardiac catheterizationStructural disease in the heart

This study presents early data in the development of a novel mouse model of heart failure utilizing thermal ablation on cardiac valves to...

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Mechanical Heart Valve Cavitation in Patients with Bileaflet Valves

Johansen, Peter ;   Andersen, Tina S. ;   Hasenkam, J. Michael ;   Nygaard, Hans ;   Paulsen, Peter K.

Tags Artificial heart and valvesHemodynamicsBlood flow

Today, the quality of mechanical heart valves is quite high, and implantation has become a routine clinical procedure with a low operative...

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Numerical Model of Total Artificial Heart Hemodynamics and the Effect of Its Size on Stress Accumulation

Marom, Gil ;   Chiu, Wei-Che ;   Slepian, Marvin J. ;   Bluestein, Danny

Tags Artificial heart and valvesBlood flow modelsCardiovascular flow and hemodynamics

The total artificial heart (TAH) is a bi-ventricular mechanical circulatory support device that replaces the heart in patients with end-stage...

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Pulsatile Operation of the BiVACOR TAH – Motor Design, Control and Hemodynamics

Kleinheyer, Matthias ;   Timms, Daniel Lee ;   Greatrex, Nicholas Anthony ;   Masuzawa, Toru ;   Frazier, O.H. ;   Cohn, William E.

Tags Artificial heart and valvesHemodynamicsBlood flow

Although there is limited consensus about the strict requirement to deliver pulsatile perfusion to the human circulatory system, speed...

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