A Metabolic Signature of Colon Cancer Initiating Cells

Chen, Kai-Yuan ;   Liu, Xiaojing ;   Bu, Pengcheng ;   Lin, Chieh-Sheng ;   Rakhilin, Nikolai ;   Locasale, Jason W. ;   Shen, Xiling

Tags Analysis of high-throughput systems biology dataBiomedical data-driven modelingModeling of gene/epigene regulatory networks

Colon cancer initiating cells (CCICs) are more tumorigenic and metastatic than the majority of colorectal cancer (CRC) cells. CCICs have also...

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A Model-Based Approach to Transcription Regulatory Network Reconstruction from Time-Course Gene Expression Data

Hu, Hong ;   Dai, Yang

Tags Analysis of high-throughput systems biology data

Time-course gene expression profiling provides valuable data on dynamic behavior of cellular responses to external stimulation. Investigation of...

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A Novel Genome-Wide Polyadenylation Sites Recognition System Based on Condition Random Field

Han, Jiuqiang ;   Zhang, Shanxin ;   Liu, Jun ;   Liu, Ruiling

Tags Analysis of high-throughput systems biology dataParameter estimationAlgorithms and techniques for systems modeling

Polyadenylation including the cleavage of pre-mRNA and addition of a stretch of adenosines to the 3'-end is an essential step of pre-mRNA...

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Comparison of Clustering Pipelines for the Analysis of Mass Spectrometry Imaging Data

Sarkari, Sanaiya ;   Kaddi, Chanchala D. ;   Bennett, Rachel ;   Fernandez, Facundo ;   Wang, May D.

Tags Analysis of high-throughput systems biology dataBiomedical data-driven modeling

Mass spectrometry imaging (MSI) is valuable for biomedical applications because it links molecular and morphological information. However, MSI...

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Detecting Vocalizations of Individual Monkeys in Social Groups

Bayestehtashk, Alireza ;   Shafran, Izhak ;   Coleman, Kristine ;   Robertson, Nicola

Tags Unstructured data visualizationAnalysis of high-throughput systems biology data

Vocalization is an important clue in recognizing monkeys' behaviors. Previous studies have shown that the frequencies, the types and the...

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Exploring Regulatory Elements in Low-Methylated Regions in DNA Methylomes for Gene Expression Prediction

Hu, Hong ;   Dai, Yang

Tags Analysis of high-throughput systems biology data

Recent studies on methylomes have indicated that low-methylated regions (LMRs) are related to potential active distal regulatory regions. To...

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Novel Prediction of Anticancer Drug Chemosensitivity in Cancer Cell Lines: Evidence of Moderation by microRNA Expressions

Yang, Daniel

Tags Analysis of high-throughput systems biology dataBiomedical data-driven modeling

The objectives of this study are (1) to develop a novel "moderation" model of drug chemosensitivity and (2) to investigate if miRNA...

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