BSSV: Bayesian Based Somatic Structural Variation Identification with Whole Genome DNA-Seq Data

Chen, Xi ;   Shi, Xu ;   Shajahan, Ayesha ;   Hilakivi-Clarke, Leena ;   Clarke, Robert ;   Xuan, Jianhua

Tags Structural bioinformaticsAnalysis of high-throughput systems biology data

High coverage whole genome DNA-sequencing enables identification of somatic structural variation (SSV) more evident in paired tumor and...

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Combining Image Processing and Modeling to Generate Traces of Beta-strands from Cryo-EM Density Images of Beta-barrels

Si, Dong ;   He, Jing

Tags Structural bioinformaticsAlgorithms and computational tools for proteomicsBiomedical data-driven modeling

Electron cryo-microscopy (Cryo-EM) technique produces 3-dimensional (3D) density images of proteins. When resolution of the images is not...

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Computational Predictions of Structures of Multichromosomes of Budding Yeast

Gursoy, Gamze ;   Xu, Yun ;   Liang, Jie

Tags Structural bioinformatics

Knowledge of the global architecture of the cell nucleus and the spatial organization of genome is critical for understanding gene expression...

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Context-Aware Semi-Supervised Motif Detection Approach

Rania Ibrahim, Rania ;   Nagia M. Ghanem, Nagia M. Ghanem ;   Mohamed A. Ismail, Mohamed A. Ismail

Tags Structural bioinformaticsAnalysis of high-throughput systems biology data

Motif detection has raised as an important task in bioinformatics. Recently, the discovery of motifs that are localized relative to a certain...

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Multi-Level Gene/MiRNA Feature Selection Using Deep Belief Nets and Active Learning

Rania Ibrahim, Rania ;   Noha A. Yousri, Noha A. Yousri ;   Mohamed A. Ismail, Mohamed A. Ismail ;   Nagwa M. El-Makky, Nagwa M. El-Makky

Tags Structural bioinformaticsMining clinical data

Selecting the most discriminative genes/miRNAs has been raised as an important task in bioinformatics to enhance disease classifiers and to...

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Structure of Collagen-Glycosaminoglycan Matrix and the Influence to Its Integrity and Stability

Bi, Yuying ;   Patra, Prabir ;   Faezipour, Miad

Tags Structural bioinformaticsNetwork modeling

Glycosaminoglycan (GAG) is a chain-like disaccharide that is linked to polypeptide core to connect two collagen fibrils/fibers and provide the...

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