A BCI Intervention for Upper-Limb Functional Movements of Chronic Stroke Patients

Ibáñez, Jaime ;   Molina Rueda, Francisco ;   Serrano, José Ignacio ;   del Castillo, María Dolores ;   Monge, Esther ;   Rivas, Francisco Miguel ;   Carratalá Tejada, Maria ;   Iglesias, Javier ;   Alguacil Diego, Isabela ;   Cuesta, Alicia ;   Cano, Roberto ;   Miangolarra, Juan Carlos ;   Pons, Jose Luis

Tags Brain functional imaging - EEGNeurological disorders - StrokeWearable systems for neurorehabilitation - Reaching and grasping

Preliminary results of a clinical validation study carried out with four chronic stroke patients along a one-month brain-computer interface...

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A Low-Cost Drop Foot Stimulator for Low Income Countries

Aqueveque, Pablo ;   Saavedra, Francisco ;   Pino, Esteban J

Tags Motor neuroprostheses - Neuromuscular stimulationMotor neuroprostheses - ProsthesesWearable systems for neurorehabilitation

This paper presents a single channel functional electrical stimulator (FES) to correct gait in people with drop foot, which was designed to...

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A Method of Connectivity Analysis of Electrocorticography in Intractable Epilepsy

Yoshioka, Yasuto ;   Yoshida, Hisashi ;   Miyauchi, Masaharu ;   Nakano, Naoki ;   Kato, Amami

Tags Connectivity measurementsSignal processing in physiological systemsSignals and systems

Surgery is an effective treatment for intractable epilepsy. In surgery, determining the epileptic foci and propagation path is the main area...

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A Novel Composite Phantom for Brain Tissue

Forte, Antonio Elia ;   Galvan, Stefano ;   Manieri, Francesco ;   Dini, Daniele

Tags Functional biomaterialsRapid prototyping for scaffold fabrication

We present a phantom of the human brain, based on a novel composite hydrogel, suitable for reproducing the brain shift phenomenon and...

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A Novel Treadmill Body Weight Support System Using Pneumatic Muscle Actuators

Tran, Van Thuc ;   Prattico, Flavio ;   Mat Dzahir, Mohd Azuwan ;   Yamamoto, Shin-ichiroh

Tags Neuromuscular systems - LocomotionWearable systems for neurorehabilitationHuman performance - Gait

This paper proposes a new Body Weight Support (BWS) system using Pneumatic Artificial Muscle (PAM) actuators with active model tracking...

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A Power Efficient Rechargeable Voltage Current Output Implantable Spinal Cord Stimulator Prototype

Hu, Yuxing ;   Ma, Bozhi ;   Hao, Hongwei ;   Wang, Weiming ;   Li, Luming ;   Chen, Yue

Tags Neural interfaces - Implantable systems

This paper introduces a Spinal Cord Stimulator (SCS) prototype, which is able to generate both of the voltage and current output in 4...

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A Transient Visual Evoked Potential (tVEP)-Based Brain Switch System

Cha, Ho-Seung ;   Lim, Jeong-Hwan ;   Han, Chang-Hee ;   Hwang, Han-Jeong ;   Chang, Won-Du ;   Im, Chang-Hwan

Tags Brain-computer/machine interface

Brain switch systems based on steady-state visual evoked potential (SSVEP) and P300 require users to stare at the quickly flickering light...

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Altered Biophysical Properties of Astrocytes in Response to Microbubbles

Sun, Shan ;   Kang, Dongkoo ;   Xiao, Shu ;   Cho, Michael

Tags Electromagnetic field effects and cell membraneMechanical stimuli and mechanotransduction

We have engineered a prototype electrical discharge system that can generate shockwaves and microbubbles of different sizes and collapse...

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An Adaptive BCI-FES System for Activation of Paralyzed Muscles in Chronic SCI Subjects

Gant, Katie ;   Xie, Ziqian ;   Sanchez, Justin C. ;   Prasad, Abhishek

Tags Motor neuroprostheses - Neuromuscular stimulationBrain-computer/machine interfaceNeurological disorders

In this study, we designed an adaptive brain computer interface-functional electrical stimulation system that was used to restore hand...

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An Analysis of Abnormal Peak in Cyclic Voltammogram of Porous Platinum Electrode

Terasawa, Yasuo ;   Tashiro, Hiroyuki ;   Nakano, Yukari ;   Oosawa, Kouji ;   Ozawa, Motoki

Tags Neural interfaces - Microelectrode technologyNeural interfaces - Implantable systemsSensory neuroprostheses - Visual

Femtosecond laser-induced porous electrodes (FLiP electrodes) have been proposed as stimulation electrodes of retinal prostheses. Cyclic...

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An Investigation of Motor Network Interactions Using Simultaneous Transcranial Magnetic Stimulation and EEG

Johnson, Nessa ;   He, Bin

Tags Brain functional imaging - Evoked potentialsBrain functional imaging - Spatial-temporal dynamicsBrain functional imaging - Connectivity and information flow

The aim of this research is to evaluate the event related activity among motor areas using a simultaneous TMS/EEG approach. Single pulses of...

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Assessing Networks of High Frequency Oscillations in Epilepsy

Malinowska, Urszula ;   Bergey, Gregory ;   Cervenka, Mackenzie C. ;   Korzeniewska, Anna ;   Jouny, Christophe

Tags Connectivity measurementsCausalityDirectionality

We propose several methods to assess the extent and directionality of networks of High Frequency Oscillations (HFO) based on intracranial...

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Baroreflex Sensitivity During Shock Induced by Intestinal Ischemia

Aletti, Federico ;   Gambarotta, Nicolò ;   Baselli, Giuseppe ;   Penn, Alexander ;   Schmid-Schönbein, Geert ;   Ferrario, Manuela

Tags Closed loop systems in physiological systemsMultivariate signal processingSignal processing in physiological systems

Baroreflex sensitivity (BRS) was investigated following splanchnic aortic occlusion (SAO) induced shock in a population of rats. BRS in the low...

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Bayesian Approach Applied on Simultaneously Recorded EEG and MEG Data to Locate the STN Electrodes

Muthuraman, Muthuraman ;   Yousuf, Mushfa ;   Helge, Hellriegel ;   Hogenboom, Nienke ;   Hartmann, Christian ;   Krause, Holger ;   Sudmeyer, Martin ;   Schnitzler, Alfons ;   Jan, Raethjen ;   Gunther, Deuschl

Tags Electrical source imaging techniquesEEG imagingMEG imaging

The purpose of this study is to locate the STN-DBS electrode using the Bayesian approach on data recorded simultaneously from both the...

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Biocompatibility of OSTE+, a Polymer with a Tunable Flexibility

Ejserholm, Fredrik ;   Stegmayr, John ;   Bauer, Patrik ;   Johansson, Fredrik ;   Wallman, Lars ;   Bengtsson, Martin ;   Oredsson, Stina

Tags Neural interfaces - BiomaterialsNeural interfaces - Microfabrication technologiesNeural interfaces - Microelectrode technology

We have tested the biocompatibility of OSTE+ using MTT assays and LC-MS. The MTT assays show that OSTE+ is nontoxic if washed with water...

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Carbon Nanotube as Crosslinking Agent within a Polymeric Network

Gaharwar, Akhilesh ;   Patel, Alpesh ;   Dolatshahi-Pirouz, Alireza ;   Hongbin, Zhang ;   Rangarajan, Kaushik ;   Iviglia, Giorgio ;   Shin, Su-Ryon ;   Hussain, Mohammad Asif ;   Khademhosseini, Ali

Tags Carbon-nanotube based scaffoldingFunctional biomaterials

Carbon nanotubes (CNTs)-based nanocomposites possess unique property combinations yet its true potential use has not been achieved. In this...

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Changes in the Phase-Amplitude Coupling of High-Frequency Oscillations As a Biomarker of Parkinsonian Severity

Bello, Edward ;   Connolly, Allison ;   Baker, Kenneth ;   Netoff, Tay ;   Johnson, Matthew ;   Vitek, Jerrold

Tags Neural signal processingBrain physiology and modeling - Neural circuitsDeep brain stimulation

In a non-human primate parkinsonian model, phase-amplitude coupling was present in both beta-band phase and gamma-band phase each with...

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Characteristics of Tactile Sensation Elicited Using a Vibration Motor

Fukuoka, Yutaka ;   Aoki, Masaya

Tags Sensory neuroprosthesesSensory neuroprostheses - Signal and vision processingSensory neuroprostheses - Somatosensory

The present study investigated characteristics of tactile sensation using a vibration motor. Fifteen healthy males participated in an...

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Comparing Resting State fMRI Data Cleaning Approaches in Multiple Sclerosis Patients versus Healthy Subjects

Dipasquale, Ottavia ;   Lagana, Maria Marcella ;   Griffanti, Ludovica ;   Tavazzi, Eleonora ;   Bergsland, Niels ;   Grosso, Cristina ;   Baglio, Francesca ;   Rovaris, Marco ;   Baselli, Giuseppe

Tags Functional image analysisImage denoisingBrain image analysis

We applied different cleaning procedures on resting state fMRI of healthy subjects and multiple sclerosis patients. We considered the...

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Computational Analysis of Induced Electric Fields During Transcranial Magnetic Stimulation

Crowther, Lawrence J. ;   Hadimani, Ravi L. ;   Jiles, David C.

Tags Neural stimulation (incl deep brain stimulation)

Transcranial magnetic stimulation is a non-invasive neurostimulation method based upon the principles of electromagnetic induction. The...

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Control of Pre-Landing Activation in Lower Extremities without Knowledge of the Stepping Height

Miyazaki, Kensuke ;   Hoshino, Takayuki ;   Mabuchi, Kunihiko

Tags Neuromuscular systems - EMG processing and applicationsNeuromuscular systems - LocomotionMotor learning, neural control, and neuromuscular systems

We examined how pre-landing activation in legs was controlled without knowledge of the stepping height during stepping down.

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Decoding Analog Multiunit Activity in a Brain-Machine Interface for Individuals with Tetraplegia

Malik, Wasim Q. ;   Donoghue, John ;   Hochberg, Leigh

Tags Brain-computer/machine interfaceMotor neuroprostheses

We compare real-time brain-machine interface control achieved with human motor cortical signals namely single-unit ensemble activity and analog...

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Decoding Location and Object Neural States During Reach-To-Grasp

Rouse, Adam ;   Schieber, Marc

Tags Motor learning, neural control, and neuromuscular systemsNeuromuscular systems - Central mechanismsBrain physiology and modeling

The prediction errors of two separate linear models show that the neural states representing reach location and object grasp occur...

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Development of an EEG-Fnirs Based Online Monitoring Tool towards Delivery of Non-Invasive Brain Stimulation

Dutta, Anirban ;   Muthalib, Makii ;   Roy Chowdhury, Shubhajit ;   Guiraud, David ;   Nitsche, Michael A. ;   Perrey, Stéphane

Tags Neural interfaces - Brain stimulationBrain-computer/machine interfaceClinical neurophysiology

A method for electroencephalography (EEG)-functional near-infrared spectroscopy (fNIRS) based monitoring of cerebrobascular reactivity...

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Development of an Image-Guided Navigation Environment for Focused Ultrasound-Mediated Bilateral Non-Invasive Neuromodulation

Kim, Hyungmin ;   Lee, Wonhye ;   Yoo, Seung-Schik

Tags Neural interfaces - Brain stimulation

We developed an image-guided navigation environment for focused ultrasound (FUS)-mediated non-invasive neuromodulation, which can provide the...

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Development of Electromagnetic Stimulation Loading Bio-Reactor for Peripheral Nerve Tissue Regeneration

Okuda, Ryo ;   Nakamachi, Eiji

Tags Neural interfaces - CellularNeural interfaces - Regeneration

In this study, we focused on the electromagnetic field stimulation for peripheral nerve regenerative treatment. We applied it to achieve both...

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Development of English Braille Learning Materials for Beginning Braille Leaders

Doi, Kouki ;   Kawano, Masaru ;   Nishimura, Takahiro ;   Fujimoto, Hiroshi ;   Tanaka, Yoshihiro ;   Sawada, Mayumi ;   Oouchi, Susumu ;   Kaneko, Takeshi ;   Kanamori, Katsuhiro

Tags Tactile displays and perception

Braille is a tool used by visually impaired children and adults to read and write at their own pace; its usage has long been widespread....

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Differential Effect of Magnetic Field Orientation on the Growth Rate of Dopaminergic Neurons During Transcranial Magnetic Stimulation

Meng, Yiwen ;   Hadimani, Ravi L. ;   Anantharam, Vellareddy ;   Kanthasamy, Anumantha ;   Jiles, David C.

Tags Deep brain stimulationDeep brain stimulation - FEM-Neuron modelsNeural interfaces - Magnetic sensors

We have investigated the effect of different orientation of time varying magnetic field generated by TMS coils on the growth rate of N27...

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Effects of Low Frequency Magnetic Fields on Magnetic Hybrid Thin Polyelectrolyte Films

Herrera Sandoval, Oscar Leonardo ;   Pastorino, Laura ;   Ruggiero, Carmelina ;   Bonaccurso, Elmar

Tags Functional biomaterialsSelf-assembled biomaterialsStimuli-sensitive biomaterials

Magnetic hybrid thin films based on polyelectrolyte multilayers and magnetic nanoparticles have been used as model materials for building up...

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Event-Related Potentials Caused by Kawaii Feeling in Watching Photos Selected by Heart Beat Modulation

Horie, Ryota ;   Yanagi, Miyuki ;   Ikeda, Ryo ;   Yamasaki, Yosuke ;   Yamariku, Yoshiyuki ;   Takashina, Tomomi ;   Hirayama, Yoshikazu ;   Ohkura, Michiko

Tags Brain functional imaging - Evoked potentialsBrain-computer/machine interface

We proposed a method to measure ERPs caused by kawaii feeling in watching photos efficiently. We measured ECG of participants while they...

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Gait-Related Artifacts in Electroencephalography Impact Connectivity Assessment During Walking

Snyder, Kristine ;   Kline, Julia ;   Huang, Helen ;   Ferris, Daniel

Tags Brain functional imaging - Connectivity and information flowBrain functional imaging - EEGNeuromuscular systems - Locomotion

Examining cortical connectivity during gait can help us understand cortical control in human walking. While electroencephalography (EEG) offers...

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High Definition Transcranial Direct Current Stimulation Modulates Event Related Cortical Synchronization During Mental Imagery: Evidence from Simultaneous tDCS-EEG

Roy, Abhrajeet ;   Baxter, Bryan ;   You, Albert ;   He, Bin

Tags Neural interfaces - Brain stimulationBrain functional imaging - EEG

Transcranial direct current stimulation (tDCS) is increasingly being investigated as a tool for clinical rehabilitation of cognitive disorders....

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High-Density 3D Pyramid-Shaped Microelectrode Arrays for Brain-Machine Interface Applications

Ghane-Motlagh, Bahareh ;   Sawan, Mohamad

Tags Neural interfaces - Microelectrode technologyNeural interfaces - Microfabrication technologiesBrain-computer/machine interface

This paper presents a novel, 3D, pyramid-shaped, penetrating, silicon-based microelectrode array (MEA) with a high electrode-density...

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Identifying Seizure States in Human iEEG Using Cross-Frequency Coupling

Guirgis, Mirna ;   Chinvarun, Yotin ;   Carlen, Peter L. ;   Bardakjian, Berj Luther

Tags Neurological disorders - EpilepsyNeural signals - Nonlinear analysisNeural signal processing

This study investigated the use of delta- and theta-modulated gamma and high frequency oscillations as a feature vector for a hidden Markov...

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Implementation of a Steady State Visual Evoked Potential (SSVEP) -Based Online Brain-Switch System Using a Chromatic Stimulus

Lim, Jeong-Hwan ;   Lee, Jun-Hak ;   Kim, Yong-Wook ;   Choi, Han ;   Han, Chang-Hee ;   Cha, Ho-Seung ;   Im, Chang-Hwan

Tags Brain-computer/machine interface

In the present study, we developed a steady-state visual evoked potential (SSVEP)-based brain switch system adopting a chromatic visual...

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Implicit and explicit uncertainty representation in PMd

Dekleva, Brian ;   Wanda, Paul ;   Miller, Lee ;   Kording, Konrad

Tags Brain physiology and modelingMotor learning, neural control, and neuromuscular systems

We investigated the representation of uncertainty in PMd as a monkey performed a center-out reaching task. The monkey executed center-out...

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Increasing ENG Bandwidth to Improve SNR in Chronic Recordings

Eggers, Thomas ;   Dweiri, Yazan ;   McCallum, Grant ;   Durand, Dominique

Tags Neural signal processingNeural interfaces - Implantable systemsNeural interfaces - Body interfaces

Although ENG contains important information about voluntary motor and sensory signals, the signal to noise ratio (SNR) is usually quite low....

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Independent Component Analysis of Gait-Related Artifact in Electroencephalography Produces Few Cortical Sources

Snyder, Kristine ;   Kline, Julia ;   Huang, Helen ;   Ferris, Daniel

Tags Brain functional imaging - Blind source separationBrain functional imaging - EEGNeuromuscular systems - Locomotion

Analysis of electroencephalography (EEG) data shows great promise for examining neural activity within a walking stride. EEG has inherently...

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Low-Intensity Pulsed Ultrasound to Increase Monoclonal Antibody Production in CHO Cells

Chen, JIe ;   Zhao, Yupeng ;   Xing, Jida ;   Xing, James

Tags Mechanical stimuli and mechanotransduction

It was found that daily ultrasound treatments at 40 mW/cm2 for 5 minutes during cell culture increased the production of human anti-IL-8...

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Manipulations of Visual Feedback Modulate Purkinje Cell Simple Spike Encoding of Error Signals During a Manual Random Tracking Task

Streng, Martha ;   Popa, Laurentiu ;   Ebner, Timothy

Tags Motor learning, neural control, and neuromuscular systemsNeuromuscular systems - Central mechanismsNeuromuscular systems - Learning and adaption

Recent research from our laboratory has indicated a role for Purkinje cell simple spikes in the encoding of motor errors consistent with a...

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Phantom Sensation Induced by Waving a Quartz Crystal at the Phantom Limb Site

Huang, Chi-Yu ;   Hsu, Kai-Hsiung ;   Yang, Rong-Sen ;   Chen, Jyh-Horng

Tags Clinical neurophysiologyNeurological disorders

This study showed a cool phantom sensation induced by waving a quartz crystal at the phantom limb site of an amputee. The somatosensory...

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Predicting Stimulus Frequencies to Disrupt Periodically Firing Neurons in the Basal Ganglia Network Using Phase Response Curves

Holt, Abbey ;   Netoff, Tay

Tags Deep brain stimulationBrain physiology and modeling - Neuron modeling and simulationBrain physiology and modeling - Neural dynamics and computation

We hypothesize that deep brain stimulation works by inducing chaos in the basal ganglia network, thereby disruption pathological oscillatory...

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Quantitative MRI Correlates of Hippocampal Pathology in Refractory Temporal Lobe Epilepsy

Goubran, Maged ;   Khan, Ali R. ;   Hammond, Robert ;   Ribaupierre, Sandrine ;   Mirsattari, Seyed ;   Burneo, Jorge ;   Steven, David ;   Parrent, Andrew G. ;   Peters, Terry

Tags MR neuroimagingMultivariate image analysisMultimodal imaging

The pathological basis of abnormal MRI signals is poorly understood in focal epilepsy and correlation between histology and pre-operative MRI is...

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Retinal Prosthesis– Steering the Line of Sight with Eye Movements

Caspi, Avi ;   Roy, Arup ;   Consedai, Gregoire ;   Greenberg, Robert ;   Safran, Avinoam ;   Sahel, Jose-Alain

Tags Sensory neuroprostheses - Visual

We have demonstrated that blind patients implanted with the Argus II retinal prosthesis can use eye movements to steer the electrical...

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Selective Recording of Neural Activities Chronically with Cuff Electrode

Dweiri, Yazan ;   Eggers, Thomas ;   McCallum, Grant ;   Durand, Dominique

Tags Neural interfaces - Body interfacesNeural signal processingMotor neuroprostheses

Flat interface nerve cuff electrode was used to record physiological activities of a peripheral nerve in dogs under chronic preparation. The...

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Soft, Nanocomposite Materials Significantly Reduce Micromotion Induced Stresses at Brain-Tissue Implant Interface

Sridharan, Arati ;   Nguyen, Jessica ;   Capadona, Jeffrey ;   Muthuswamy, Jit

Tags Neural interfaces - Tissue-electrode interfaceNeural interfaces - Microelectrode technologyNeural interfaces - Biomaterials

Mechanical stresses in the brain, induced by relative micromotion between implant and the surrounding brain tissue as a result of respiratory...

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Sound Speed Measurement of Weak and High-Frequency Shear Wave Generated Via Mode Conversion of Longitudinal Wave

Nii, Kohei ;   Tagawa, Norio ;   Okubo, Kan ;   Ho, Yihsin ;   Yagi, Shin-ichi

Tags Biomedical simulation involving signal processingSignal processing in physiological systemsSignals and systems

We are examining a new elastography method using the shear wave generated by a mode conversion of a longitudinal pulse at elasticity...

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Stability of Kinematic Neural Decoding with Perturbed Movements

Perich, Matthew G ;   Miller, Lee

Tags Brain-computer/machine interfaceMotor neuroprosthesesMotor learning, neural control, and neuromuscular systems

Brain-machine interfaces (BMIs) can allow paralyzed individuals to interact with the world by using neural activity as a control signal for...

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State-Space Trajectories Organized in a Recurrent Neural Learning of Opening and Closing of the Hand

Ikeda, Ryo ;   Horie, Ryota

Tags Motor neuroprosthesesMotor neuroprostheses - Robotics

Toward intuitive control of a powered upper-limb prostheses, we proposed a method to predict opening and closing of the hand from time...

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Toward High-Throughput Epileptic Engineering: Microperfusion System for Organotypic Brain Slice Culture

Liu, Jing ;   Berdichevsky, Yevgeny

Tags Neurological disorders - EpilepsyNeural interfaces - Neural microsystems and interface engineeringNeural interfaces - Tissue-electrode interface

To improve the scalability of organotypic hippocampal culture model of post traumatic epilepsy, we designed a microperfusion system for...

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Toward Transductive Learning Classifiers for Non-Stationary EEG

Raza, Haider ;   Prasad, Girijesh ;   Li, Yuhua ;   Cecotti, Hubert

Tags Brain-computer/machine interfaceNeural signal processingNeuromuscular systems - Learning and adaption

A major challenge in brain-computer interfaces (BCIs) based on electroencephalogram (EEG) signals is the immanent non-stationarities in EEG...

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