An Early Respiratory Distress Detection Method with Markov Models

Ravishankar, Hariharan ;   Saha, Aditya ;   Swamy, Gokul ;   Genc, Sahika

Tags Medical decision makingBiomedical data-driven modelingPhysiological systems

A method for early detection of respiratory distress in hospitalized patients which is based on a multi-parametric analysis of respiration...

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Biomarkers from Biosimulations: Transcriptome-To-Reactome? Technology for Individualized Medicine

Phelix, Clyde ;   Villareal, Greg ;   LeBaron, Richard ;   Roberson, Dawn

Tags Medical decision makingModeling of biomolecular system pathwaysBiomedical data-driven modeling

We validated a model of the TGF-? signaling pathway using reactions from Reactome. Using a patent-pending technique, gene expression profiles...

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Classification of Serous Ovarian Tumors Based on Microarray Data Using Multicategory Support Vector Machines

Park, Jee Soo ;   Choi, Soo Beom ;   Chung, Jai Won ;   Kim, Sung Woo ;   Kim, Deok Won

Tags Medical decision makingAnalysis of high-throughput systems biology dataMining clinical data

Ovarian cancer, the most fatal of reproductive cancers, is the fifth leading cause of death in women in the United States. Serous borderline...

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Correcting Hypothalamic-Pituitary-Adrenal Axis Dysfunction Using Observer-Based Explicit Nonlinear Model Predictive Control

Chakrabarty, Ankush ;   Buzzard, Greg T. ;   Corless, Martin J. ;   Zak, Stanislaw ;   Rundell, Ann E.

Tags Medical decision makingParameter estimation

The hypothalamic-pituitary-adrenal (HPA) axis is critical in maintaining homeostasis under physical and psychological stress by modulating...

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Deformable Image Tracking of the Parotid Gland for Adaptive Radiotherapy Application

Raad, Ali ;   Ayache, Mohammad ;   Abboud, Alaa ;   permezel, Astrid ;   Merzouki, Rochdi ;   Lartigau, Eric

Tags Medical decision makingAlgorithms and techniques for systems modelingBiomedical data-driven modeling

Radiation therapy is a type of cancer treatment using radiation at different times defined as treatment sessions, distributed over different...

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Hemodynamic-Impact-Based Prioritization of Ventricular Tachycardia Alarms

Desai, Kalpit V. ;   Lexa, Michael ;   Matthews, Brett ;   Genc, Sahika

Tags Medical decision makingMining clinical dataBiomedical data-driven modeling

Ventricular tachycardia (V-tach) is a very serious condition that occurs when the ventricles are driven at high rates. The abnormal...

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Identifying Homogeneous Subgroups for Individual Patient Meta-Analysis Based on Rough Set Theory

Gil-Herrera, Eleazar ;   Tsalatsanis, Athanasios ;   Kumar, Ambuj ;   Mhaskar, Rahul ;   Miladinovic, Branko ;   Yalcin, Ali ;   Djulbegovic, Benjamin

Tags Mining clinical dataMedical decision makingComparative effectiveness research

Failure to detect and manage heterogeneity between clinical trials included in meta-analysis may lead to misinterpretation of summary effect...

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Mathematical Models for Absorption and Efficacy of Ovarian Cancer Treatments

Zou, Jianmin ;   Gundry, Stephen ;   Ganic, Emir ;   Uyar, M. Umit

Tags Medical decision makingPK/PDBiomedical data-driven modeling

The creation of personal and individualized anti-cancer treatments has been a major goal in the progression of cancer discovery as evident...

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Multicategory Classification of 11 Neuromuscular Diseases Based on Microarray Data Using Support Vector Machine

Choi, Soo Beom ;   Park, Jee Soo ;   Chung, Jai Won ;   Yoo, Tae Keun ;   Kim, Deok Won

Tags Medical decision makingAnalysis of high-throughput systems biology dataMining clinical data

We applied multicategory machine learning methods to classify 11 neuromuscular disease groups and one control group based on microarray data....

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