Feature Selection for Discrimination of Fractionation Levels in Atrial Electrograms

Orozco-Duque, Andres ;   Martínez-Vargas, Juan David ;   Novak, Daniel ;   Bustamante, John ;   Castellanos-Dominguez, Germán

Radiofrequency catheter ablation of atrial fibrillation (AF) guided by complex fractionated atrial electrograms (CFAE) is associated with a high AF termination rate in paroxysmal AF, but not in persistent. CFAE does not always identify favorable sites for persistent AF ablation. Studies suggest that only high fractionation level should be used as a target site for ablation. Nonetheless, there are not a standardized criterion to defined fractionation levels. Therefore, a better characterization of the signal is required providing a set of more powerful features that should be extracted from CFAE. Due to the apparent difference among fractionation classes in terms of their stochastic variability, we test time-domain and time-frequency based feature extraction approaches. Also, we carried out the symmetrical uncertainty-based feature selection to determine the most relevant features which improve discrimination of fractionation levels. Obtained results on a tested real electrogram database show that most relevant features in time-domain are related with time intervals and not with amplitudes. Nonetheless, time-frequency features obtained more information from the signal and this representation is likely a better suitable discriminating approach, particularly to detect high fragmented electrograms with a sensitivity and specificity of 83.0% and 93.6%, respectively.