Biclustering for ssDNA Aptamer Motif Prototypes

Moore, Erin J. ;   Bourlai, Thirimachos

Tags Data miningComputational systems biologyPersonalized health/precision medicine

Aptamers and biclustering are enabling technologies for personalized medicine. Aptamers are highly valuable for medicine and biosensors, but...

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Comparison of Some Machine Learning and Statistical Algorithms for Classification and Prediction of Human Cancer Type

Shamsaei, Behrouz ;   Gao, Cuilan Lani

Tags Machine learningGene expression pattern recognitionComputational disease profiling

Use of gene expression profile of an animal under a certain disease gives pre-clinical insights for the potential efficacy of novel drugs....

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Gene Selection and Classification Approach for Microarray Data based on Random Forest Ranking and BBHA

Pashaei, Elnaz ;   Ozen, Mustafa ;   Aydin, Nizamettin

Tags Gene expression pattern recognitionDecision support systemsMachine learning

In this paper, a novel approach based on Binary Black Hole Algorithm (BBHA) and Random Forest Ranking (RFR) is proposed for gene selection...

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GPU Acceleration for Bayesian Control of Markovian Genetic Regulatory Networks

Zhou, He ;   Hu, Jiang ;   Khatri, Sunil ;   Liu, Frank ;   Sze, Cliff Chin Ngai ;   Rezaei Yousefi, Mohammadmahdi

Tags Personalized health/precision medicineComputational systems biologyHigh-performance computing for healthcare

A recently developed approach to precision medicine is the use of Markov Decision Processes (MDPs) on Gene Regulatory Networks (GRNs). Due...

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Integrating Information on Genomics, Transcriptomics, Proteomics, and Metabolomics into Biosimulations for Individualized Personalized Medicine

Phelix, Clyde ;   Dugan, Jason

Tags Personalized health/precision medicineComputational modeling and simulations in biology, physiology and medicinePharmaco-genomics

Current genomic tests reporting single nucleotide polymorphisms (SNPs) have limited predictability on individual patient responses to drugs. ...

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Splice Sites Prediction of Human Genome using AdaBoost

Pashaei, Elham ;   Ozen, Mustafa ;   Aydin, Nizamettin

Tags Decision support methods and systemsMachine learningComputational systems biology

With the rapid growth of huge amounts of DNA sequence, gene prediction has become a challenging problem in bioinformatics. Splice sites...

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